Evaluation of gut-blood barrier dysfunction in various models of trauma, hemorrhagic shock, and burn injury

L Wrba, A Palmer, CK Braun… - … Trauma and Acute Care …, 2017 - journals.lww.com
permeability is known to be increased and associated with disease severity. Permeability
changes are also observed in patients … Transmigration of microbiotic products via a defective

[HTML][HTML] Pathophysiology in patients with polytrauma

HC Pape, EE Moore, T Mckinley, A Sauaia - Injury, 2022 - Elsevier
… of hypoperfusion are most relevant due to the endothelial permeability changes, it was
discovered that the innate immune response to trauma is equally important in modifying the organ …

[HTML][HTML] Management of aesthetic and functional deficits in frontal bone trauma

M Dumitru, D Vrinceanu, B Banica, R Cergan, IA Taciuc… - Medicina, 2022 - mdpi.com
… are necessary but maintain FND permeability [23]. Displaced … reconstruction of the defects
using metal plates (Figure 7). … Moreover, the team caring for the trauma patient should be as …

[HTML][HTML] Temporal and spatial effects of blast overpressure on blood-brain barrier permeability in traumatic brain injury

M Kuriakose, KV Rama Rao, D Younger, N Chandra - Scientific reports, 2018 - nature.com
Blast-induced traumatic brain injury (bTBI) is a “signature wound” in soldiers during training
and in combat and has also become a major cause of morbidity in civilians due to increased …

Role of metabolic changes of mucosal layer in the intestinal barrier dysfunction following trauma/hemorrhagic shock

R Zhu, X Ma - Pathology-Research and Practice, 2018 - Elsevier
… THS has a high cost-of-burden and adversely affects the quality of life of the patients. Studies
have … In conclusion, THS caused gut barrier dysfunction by increasing permeability, and …

History of the innovation of damage control for management of trauma patients: 1902–2016

DJ Roberts, CG Ball, DV Feliciano, EE Moore… - Annals of …, 2017 - journals.lww.com
… or defective synthesis of clotting factors. In 1978, Clagett and Olsen 24 observed that 52% of
… injury of the bowel, increased intestinal permeability, and heightened sequestration of fluid …

Update on the role of endothelial cells in trauma

J Greven, R Pfeifer, Q Zhi, HC Pape - European Journal of Trauma and …, 2018 - Springer
… IL-1β alters the permeability dependent on tissue factor (TF), and could be a future target
for treatment of acute trauma patients [30]. This increase in permeability can result in immune …

[HTML][HTML] Why are bleeding trauma patients still dying? Towards a systems hypothesis of trauma

GP Dobson, JL Morris, HL Letson - Frontiers in physiology, 2022 - frontiersin.org
trauma patient requires emergent surgery, the body is further stressed by the next surge of
damage signals from the trauma … A better understanding on why bleeding trauma patients are …

Traumatic-induced coagulopathy as a systems failure: a new window into hemostasis

GP Dobson, JL Morris, LM Davenport… - … in Thrombosis and …, 2020 - thieme-connect.com
… 310 trauma patients had delayed platelet activation in the PFA-100 test, suggesting a defect
… of membrane potential, opening of the mitochondrial permeability transition pore, Ca 2+ …

[HTML][HTML] A narrative review of changes in microvascular permeability after burn

Y Chi, X Liu, J Chai - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
… components of the vascular endothelium of trauma patients fall off and the colloidal osmotic
… and thrombin loss after trauma, which affects permeability and coagulation function (26). …