Functional regions of the peroxin Pex19 necessary for peroxisome biogenesis

G Agrawal, HH Shang, ZJ Xia, S Subramani - Journal of Biological …, 2017 - ASBMB
Pex19 plays multiple roles in these processes, but how these functions relate to the … of
the Pex19 domains is unresolved. To this end, using deletion mutants, we mapped the Pex19

Comparative genomics of peroxisome biogenesis proteins: making sense of the PEX proteins

RLM Jansen, C Santana-Molina… - Frontiers in cell and …, 2021 - frontiersin.org
… , PEX19 and PEX16. PMPs can sort directly to peroxisomes or indirectly via the ER. In the
direct pathway PEX19 … The Pex11 protein family (all show as PEX11) and the fungal peroxins

[HTML][HTML] Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26

P Guder, AS Lotz-Havla, M Woidy, DD Reiß… - … et Biophysica Acta (BBA …, 2019 - Elsevier
… In order to better understand the role of this peroxin in … line with our data using artificial
fragments for domain mapping. … HR2 are an essential part of the PEX19 binding domain. Our data …

Molecular insights into peroxisome homeostasis and peroxisome biogenesis disorders

Y Fujiki, K Okumoto, M Honsho, Y Abe - Biochimica et Biophysica Acta …, 2022 - Elsevier
Peroxins are functionally divided into three groups: (i) Pex3, Pex16 and Pex19 function in
peroxisome membrane assembly by class I and II pathways; (ii) ten peroxins play pivotal roles …

Structural mapping of missense mutations in the Pex1/Pex6 complex

A Schieferdecker, P Wendler - International journal of molecular sciences, 2019 - mdpi.com
… , and PEX19 are all implicated in the protein import machinery. Variations in these peroxins
… Most of these cases are attributed to mutations in peroxins Pex1 (60%) and Pex6 (16%) [1,5]…

Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains

B Schrul, RR Kopito - Nature cell biology, 2016 - nature.com
… In this study we identified PEX19 and BAG6 as direct HP-domain-specific binding partners
of newly synthesized UBXD8 and provide three lines of evidence supporting the conclusion …

Peroxisome function relies on organelle-associated mRNA translation

N Dahan, YS Bykov, EA Boydston, A Fadel, Z Gazi… - Science …, 2022 - science.org
… Because Pex14 contains a Pex19 binding domain at its N terminus (7), the most trivial …
of Pex19 was visualized in strains that were previously described in which these peroxins are …

Insights into the structure and function of the Pex1/Pex6 AAA-ATPase in peroxisome homeostasis

RM Judy, CJ Sheedy, BM Gardner - Cells, 2022 - mdpi.com
domains that serves as a recognition site for the cytosolic PMP receptor, Pex19 [35,36]. …
domain to the C-terminus is important for binding to Pex19 and peroxisome targeting [198]. …

Pex13 and Pex14, the key components of the peroxisomal docking complex, are required for peroxisome formation, host infection and pathogenicity-related …

JY Wang, L Li, RY Chai, HP Qiu, Z Zhang, YL Wang… - Virulence, 2019 - Taylor & Francis
… matrix proteins are commonly termed peroxins. Peroxin-encoding genes are designated …
We have previously demonstrated the involvement of Pex19 and Pex11 in the biogenesis of …

Peroxisome biogenesis, membrane contact sites, and quality control

JC Farré, SS Mahalingam, M Proietto, S Subramani - EMBO reports, 2019 - embopress.org
Pex19 is an acidic peroxin that associates with membranes through its C‐terminal farnesyl
tail, and … The binding of Pex19 near the TMDs of such PMPs facilitates the role of Pex19 as a …