Fluid metabolic pathways after subarachnoid hemorrhage

J Zhou, P Guo, Z Guo, X Sun, Y Chen… - Journal of …, 2022 - Wiley Online Library
… Starting from the point at which blood enters the subarachnoid space from a ruptured
aneurysm, this paper summarizes the fluid clearance pathway of blood and hemolytic products in …

The effects of blood and blood products on the arachnoid cell

EA Hansen, L Romanova, C Janson… - Experimental Brain …, 2017 - Springer
… blood cells and hemolytic products are deposited intracranially … subarachnoid space triggers
vasospasm. It also incites fibrosis of the arachnoid membrane and the subarachnoid space, …

[HTML][HTML] Haptoglobin administration into the subarachnoid space prevents hemoglobin-induced cerebral vasospasm

M Hugelshofer, RM Buzzi, CA Schaer… - The Journal of …, 2019 - Am Soc Clin Investig
… been defined in models of systemic hemolysis, such as sickle-cell … In systemic hemolysis,
haptoglobin blocks cell-free Hb … In this study, we used a plasma-derived haptoglobin product, …

Targeting hemoglobin to reduce delayed cerebral ischemia after subarachnoid hemorrhage

HA Zeineddine, P Honarpisheh, D McBride… - Translational stroke …, 2022 - Springer
… released into the subarachnoid space. After the bleeding stops, RBC hemolysis and release
of … role for lysed erythrocytes’ products within the subarachnoid space in the pathogenesis of …

Clearance of Subarachnoid Hemorrhage from the Cerebrospinal Fluid in Computational and In Vitro Models

K Tangen, NS Narasimhan, K Sierzega… - Annals of biomedical …, 2016 - Springer
… causing blood to leak into the cranial subarachnoid space (SAS). Hemorrhage volume has
… occurrence of vasospasm is attributed to the hemolysis of blood which contributes to DCI.26 …

Cell-free oxyhemoglobin in cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: biomarker and potential therapeutic target

M Hugelshofer, CM Sikorski, M Seule, J Deuel… - World neurosurgery, 2018 - Elsevier
… erythrocytes into the subarachnoid space and its breakdown products in the cerebrospinal
… been characterized in animal models of systemic hemolysis and are related to vascular nitric …

An introduction to the pathophysiology of aneurysmal subarachnoid hemorrhage

JH van Lieshout, M Dibué-Adjei, JF Cornelius… - Neurosurgical …, 2018 - Springer
… The extravasation of blood in the subarachnoid space leads to intense headache and an …
and partially by breakdown products such as bilirubin oxidation products (BOXes) which have …

[HTML][HTML] Cerebrospinal fluid macrophage migration inhibitory factor: a potential predictor of cerebral vasospasm and clinical outcome after aneurysmal subarachnoid …

K Kwan, O Arapi, KE Wagner, J Schneider, HL Sy… - Journal of …, 2019 - thejns.org
… cell lysis lead to the release of hemoglobin products into the subarachnoid space. This has
subarachnoid space. There were elevated rates of clinical infection and sample hemolysis in …

[HTML][HTML] Analysis of blood degradation products and ferritin in the cerebrospinal fluid of dogs with acute thoracolumbar intervertebral disk extrusion, a prospective pilot …

S Bittermann, C Schild, E Marti, J Mirkovitch… - BMC veterinary …, 2019 - Springer
… from in vitro hemolysis after a traumatic puncture [43]. … products such as oxyhemoglobin,
bilirubin and ferritin in lumbar CSF to demonstrate hemorrhage in the subarachnoidal space of …

Cerebrospinal fluid hemoglobin drives subarachnoid hemorrhage-related secondary brain injury

K Akeret, RM Buzzi, CA Schaer… - Journal of Cerebral …, 2021 - journals.sagepub.com
… accumulate in the subarachnoid space after aSAH. In in-vitro studies and in hemolytic mice,
… of resident and recruited macrophages in the subarachnoid space at that time point (Figure …