Current and emerging therapies for metastatic castration-resistant prostate cancer (mCRPC)

I Henríquez, M Roach III, TM Morgan, A Bossi… - Biomedicines, 2021 - mdpi.com
Prostate cancer (PCa) is one of the most common cancers in men. In the year 2020, an …
-resistant prostate cancer (mCRPC). The long-term prognosis for patients with mCRPC is poor, …

Update on systemic prostate cancer therapies: management of metastatic castration-resistant prostate cancer in the era of precision oncology

P Nuhn, JS De Bono, K Fizazi, SJ Freedland, M Grilli… - European urology, 2019 - Elsevier
… the management of advanced prostate cancer provides a range of treatment options with
notable benefits for men with metastatic castration-resistant prostate cancer (mCRPC). At the …

Novel therapies are changing treatment paradigms in metastatic prostate cancer

E Powers, GS Karachaliou, C Kao, MR Harrison… - Journal of hematology & …, 2020 - Springer
prostate cancer (mCRPC) … mCRPC and mutations in DNA damage repair genes has added
to the treatment armamentarium and improved personalized treatments for prostate cancer. …

KEYNOTE-199: Pembrolizumab (pembro) for docetaxel-refractory metastatic castration-resistant prostate cancer (mCRPC).

JS De Bono, JCH Goh, K Ojamaa… - 2018 - ascopubs.org
… -scale mCRPC trials. Pembro showed preliminary antitumor activity in PD-L1+ mCRPC in …
of pembro monotherapy in docetaxel-refractory mCRPC (NCT02787005). Methods: Cohorts …

Avelumab in metastatic castration-resistant prostate cancer (mCRPC).

F Fakhrejahani, RA Madan, WL Dahut, F Karzai… - 2017 - ascopubs.org
… /kg of avelumab in pts with mCRPC who had progressive disease (… Prostate cancer working
group 2 criteria were used to … on a population of pts with mCRPC. Immune analysis is under …

[HTML][HTML] Prostate-specific membrane antigen heterogeneity and DNA repair defects in prostate cancer

A Paschalis, B Sheehan, R Riisnaes, DN Rodrigues… - European urology, 2019 - Elsevier
… DDR = defective DNA repair; FPKM = Fragments Per Kilobase of transcript per Million
mapped reads; mCRPC = metastatic castration-resistant prostate cancer; PSMA = …

Real-world treatment patterns and overall survival among men with Metastatic Castration-Resistant Prostate Cancer (mCRPC) in the US Medicare population

SJ Freedland, M Davis, AJ Epstein… - … Cancer and Prostatic …, 2024 - nature.com
… of metastatic castration-resistant prostate cancer (mCRPC), increasing options available to
… of men with mCRPC. Toward this effort, recent studies evaluated mCRPC treatment patterns …

Treatment of advanced prostate cancer—A review of current therapies and future promise

S Sumanasuriya, J De Bono - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
… Despite many recent advances in the therapy for metastatic castration-resistant prostate
cancer (mCRPC), the disease remains incurable, although men suffering from this disease are …

[HTML][HTML] Real-world use of systemic therapies in men with metastatic castration resistant prostate cancer (mCRPC) in Canada

B Shayegan, CJD Wallis, S Malone, I Cagiannos… - … Oncology: Seminars and …, 2022 - Elsevier
Prostate cancer is the most common non-cutaneous cancerprostate cancer (CRPC), or
metastatic CRPC (mCRPC), … in addition to ADT in the mCRPC setting has grown quickly, starting …

Past, current, and future of immunotherapies for prostate cancer

AN Boettcher, A Usman, A Morgans… - Frontiers in …, 2019 - frontiersin.org
… metastatic castration-resistant prostate cancer (mCRPC), of … types of cancer, but only a
marginal benefit for mCRPC, at … nature of the prostate tumor microenvironment, including …