… 10 ,23 have suggested a synergistic association between metformin and EGFR-TKIs in
EGFR-mutated lung cancer cell lines, and the combination of metformin plus erlotinib or gefitinib …

… first-generation EGFR TKIs (eg, gefitinib and erlotinib) is approximately 10 to 12 months.10, …
, is a superior first-line therapy according to the FLAURA study, 11 , 12 there is no standard …

… Subsequent clinical trials have shown the significant efficacy of epidermal growth factor …
(gefitinib, erlotinib, and afatinib) for the therapy of NSCLC in Japan. Phase III clinical trials have …

… is also associated with significantly longer PFS than gefitinib or erlotinib when used as first-…
resistant to gefitinib or erlotinib could cross over to osimertinib in the FLAURA study. Thus, we …

… gefitinib or erlotinib. A large phase 2B randomized controlled trial comparing the efficacy of
gefitinib … The result of this study provides evidence that gefitinib, erlotinib, and afatinib have …

… No study has compared these two generations of EGFR-TKIs in this patient population. Herein,
we conducted a retrospective study to assess the efficacy of gefitinib/erlotinib … Clinical trial …

… randomized controlled trials comparing EGFR TKIs were published recently. CTONG 0901,
comparing first-line erlotinib to gefitinib in … similar between erlotinib-treated or gefitinib-treated …

… in EGFR-mutant tumors, and clinical studies have shown a positive association between …
progression after treatment with gefitinib or erlotinib.3, 4 KEYNOTE-021 (ClinicalTrials.gov , …

… Although in the FLAURA trial, the OS benefit with osimertinib versus gefitinib/erlotinib was …
global interventional clinical studies conducted for medicines, vaccines and medical devices (1…

… In this study, we evaluated the economic superiority of afatinib to gefitinib and erlotinib as …
-small-cell lung cancer’, and was narrowed down to include randomized controlled trials. …