Abstract Background Approximately 70% of Alzheimer's disease (AD) patients have co-
morbid vascular contributions to cognitive impairment and dementia (VCID); this highly …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

In the past few decades, the prevalence of obesity and type 2 diabetes mellitus (T2DM), as
well as older individuals at risk for Alzheimer's disease (AD), has increased. While the …

The effects of fasting-mimicking diet (FMD) cycles in reducing many aging and disease risk
factors indicate it could affect Alzheimer's disease (AD). Here, we show that FMD cycles …

Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

Multiple factors of metabolic syndrome have been implicated in the pathogenesis of
Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine …

Alzheimer's disease (AD) is the most common form of dementia. Obesity in middle age
increases AD risk and severity, which is alarming given that obesity prevalence peaks at …

Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported that obesity accelerates AD-related pathophysiology and memory impairment in …

Abstract Type 2 diabetes (T2D) is associated with increased risk of Alzheimer's disease
(AD). There is evidence for impaired blood–brain barrier (BBB) in both diseases, but its role …

Although type 2 diabetes is a well-known risk factor for Alzheimer's disease (AD), little is
known about how its precursor—prediabetes—impacts neuropsychological function and …