Protein kinase A–dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1
Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …
AMP-activated protein kinase activity is critical for hypoxia-inducible factor-1 transcriptional activity and its target gene expression under hypoxic conditions in DU145 …
M Lee, JT Hwang, HJ Lee, SN Jung, I Kang… - Journal of Biological …, 2003 - ASBMB
AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic
adaptations under the ATP-deprived conditions such as hypoxia. In the present study, we …
adaptations under the ATP-deprived conditions such as hypoxia. In the present study, we …
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
A Kalousi, I Mylonis, AS Politou… - Journal of cell …, 2010 - journals.biologists.com
Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …
Signal transduction to hypoxia-inducible factor 1
GL Semenza - Biochemical pharmacology, 2002 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …
Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1
The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumour
growth and progression, and HIF-1 is regulated through a number of signalling pathways …
growth and progression, and HIF-1 is regulated through a number of signalling pathways …
Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin
CC Hudson, M Liu, GG Chiang… - … and cellular biology, 2002 - Taylor & Francis
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …
Molecular responses to hypoxia-inducible factor 1α and beyond
J Brocato, Y Chervona, M Costa - Molecular pharmacology, 2014 - ASPET
Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …
eIF2α Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1α
AI Papadakis, E Paraskeva, P Peidis, H Muaddi, S Li… - Cancer research, 2010 - AACR
Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …
Transduction pathways involved in Hypoxia-Inducible Factor-1 phosphorylation and activation
Hypoxia-Inducible Factor-1 (HIF-1) is a transcription factor which is activated by hypoxia and
involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress …
involved in the adaptative response of the cell to oxygen deprivation. During hypoxic stress …