Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes encoding proteins that
enable cells to adapt to reduced O2 availability. Proteins encoded by HIF-1 target genes …

AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic
adaptations under the ATP-deprived conditions such as hypoxia. In the present study, we …

Hypoxia-inducible factor 1 (HIF-1), a transcriptional activator that mediates cellular response
to hypoxia and a promising target of anticancer therapy, is essential for adaptation to low …

Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator that functions as a master
regulator of O2 homeostasis. HIF-1 target genes encode proteins that increase O2 delivery …

Hypoxia-inducible factors (HIF) are a family of heterodimeric transcriptional regulators that
play pivotal roles in the regulation of cellular utilization of oxygen and glucose and are …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an
inducibly expressed HIF-1α subunit and a constititutively expressed HIF-1β subunit. Under …

The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumour
growth and progression, and HIF-1 is regulated through a number of signalling pathways …

Cellular response to changes in oxygen tension during normal development or pathologic
processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive …

Hypoxia within the tumor microenvironment promotes angiogenesis, metabolic
reprogramming, and tumor progression. In addition to activating hypoxia-inducible factor-1α …

Hypoxia-inducible factor 1 (HIF-1) plays a critical role in controlling oxygen delivery and
metabolic adaptation to hypoxic conditions in hypoxic tumor cells. HIF-1 activation is initiated …