Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators
MAC Déry, MD Michaud, DE Richard - … journal of biochemistry & cell biology, 2005 - Elsevier
Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …
Modulating the hypoxia-inducible factor signaling pathway: applications from cardiovascular disease to cancer
KS Hewitson, LA McNeill… - Current pharmaceutical …, 2004 - ingentaconnect.com
Humans, like other complex aerobic organisms, possess highly evolved systems for the
delivery of dioxygen to all the cells of the body. These systems are regulated since …
delivery of dioxygen to all the cells of the body. These systems are regulated since …
Functional regulation of HIF‐1α under normoxia—is there more than post‐translational regulation?
A Kuschel, P Simon, S Tug - Journal of cellular physiology, 2012 - Wiley Online Library
Abstract The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …
Differential hypoxic regulation of hypoxia-inducible factors 1α and 2α
Q Lin, X Cong, Z Yun - Molecular Cancer Research, 2011 - AACR
The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …
[HTML][HTML] HIF-1 Interacts with TRIM28 and DNA-PK to release paused RNA polymerase II and activate target gene transcription in response to hypoxia
Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …
Suppression of the dual-specificity phosphatase MKP-1 enhances HIF-1 trans-activation and increases expression of EPO
C Liu, Y Shi, Z Han, Y Pan, N Liu, S Han, Y Chen… - Biochemical and …, 2003 - Elsevier
Hypoxia-inducible factor 1 (HIF-1) is a phosphorylated protein and its phosphorylation is
involved in HIF-1α subunit stabilization as well as in the regulation of HIF-1 transcriptional …
involved in HIF-1α subunit stabilization as well as in the regulation of HIF-1 transcriptional …
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
M Koshiji, Y Kageyama, EA Pete, I Horikawa… - The EMBO …, 2004 - embopress.org
Hypoxia induces angiogenesis and glycolysis for cell growth and survival, and also leads to
growth arrest and apoptosis. HIF‐1α, a basic helix–loop–helix PAS transcription factor, acts …
growth arrest and apoptosis. HIF‐1α, a basic helix–loop–helix PAS transcription factor, acts …
c-Jun NH2-Terminal Kinase Activation Contributes to Hypoxia-Inducible Factor 1α–Dependent P-Glycoprotein Expression in Hypoxia
KM Comerford, EP Cummins, CT Taylor - Cancer research, 2004 - AACR
We previously have shown that hypoxia increases the expression of P-glycoprotein, which in
turn increases tumor cell capacity to actively extrude chemotherapeutic agents and may …
turn increases tumor cell capacity to actively extrude chemotherapeutic agents and may …
Hypoxia, HIF-1, and the pathophysiologi of common human diseases
GL Semenza, F Agani, D Feldser, N Lyer… - … sensing: molecule to …, 2002 - Springer
Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …
Hypoxia-inducible factor (HIF): fuel for cancer progression
S Satija, H Kaur, MM Tambuwala… - Current molecular …, 2021 - ingentaconnect.com
Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly
multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic …
multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic …