Oxygen availability is crucial for cellular metabolism. Hypoxia-inducible factor 1 (HIF-1) is
the major oxygen homeostasis regulator. Under normoxic conditions, HIF-1 is rapidly …

Humans, like other complex aerobic organisms, possess highly evolved systems for the
delivery of dioxygen to all the cells of the body. These systems are regulated since …

Abstract The hypoxia‐inducible factor‐1 (HIF‐1) is an oxygen‐regulated transcriptional
activator playing a pivotal role in mammalian physiology and disease pathogenesis, eg, HIF …

The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …

Abstract Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that acts as a regulator of
oxygen (O2) homeostasis in metazoan species by binding to hypoxia response elements …

Hypoxia-inducible factor 1 (HIF-1) is a phosphorylated protein and its phosphorylation is
involved in HIF-1α subunit stabilization as well as in the regulation of HIF-1 transcriptional …

Hypoxia induces angiogenesis and glycolysis for cell growth and survival, and also leads to
growth arrest and apoptosis. HIF‐1α, a basic helix–loop–helix PAS transcription factor, acts …

We previously have shown that hypoxia increases the expression of P-glycoprotein, which in
turn increases tumor cell capacity to actively extrude chemotherapeutic agents and may …

Hypoxia plays a fundamental role in the pathophysiology of common causes of mortality,
including ischemic heart disease, stroke, cancer, chronic lung disease, and congestive heart …

Hypoxia is an integral part of the tumor microenvironment, caused primarily due to rapidly
multiplying tumor cells and a lack of proper blood supply. Among the major hypoxic …