Metabolism, pharmacokinetics and excretion of [14C]dimethyl fumarate in healthy volunteers: an example of xenobiotic biotransformation following endogenous …

L Xu, CC Peng, K Dawson, S Stecher, J Woodworth… - Xenobiotica, 2023 - Taylor & Francis
Delayed–release dimethyl fumarate (DMF), Tecfidera®, is approved globally for treating
relapsing-remitting multiple sclerosis. The disposition of DMF was determined in humans …

Alcohol inhibits the metabolism of dimethyl fumarate to the active metabolite responsible for decreasing relapse frequency in the treatment of multiple sclerosis

B Yang, RB Parker, B Meibohm, ZH Temrikar… - Plos one, 2022 - journals.plos.org
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting
multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF) …

Pharmacokinetics and Bioavailability of Monomethyl Fumarate Following a Single Oral Dose of Bafiertam™ (Monomethyl Fumarate) or Tecfidera® (Dimethyl …

TW Lategan, L Wang, TN Sprague, FS Rousseau - CNS drugs, 2021 - Springer
Background Tecfidera®(dimethyl fumarate [DMF]) is an approved product for the treatment
of relapsing forms of multiple sclerosis. Monomethyl fumarate (MMF) is the only active …

[HTML][HTML] Tolerability and pharmacokinetics of delayed-release dimethyl fumarate administered with and without aspirin in healthy volunteers

SI Sheikh, I Nestorov, H Russell, J O'Gorman… - Clinical …, 2013 - Elsevier
Background Delayed-release dimethyl fumarate (DR-DMF) has cytoprotective and
antiinflammatory properties and has recently been approved in the United States as an oral …

Diroximel fumarate demonstrates an improved gastrointestinal tolerability profile compared with dimethyl fumarate in patients with relapsing–remitting multiple …

RT Naismith, A Wundes, T Ziemssen, E Jasinska… - CNS drugs, 2020 - Springer
Background Diroximel fumarate (DRF) is a novel oral fumarate approved in the USA for
relapsing forms of multiple sclerosis. DRF is converted to monomethyl fumarate, the …

Dimethyl fumarate transfer into human milk

AI Ciplea, P Datta, K Rewers-Felkins… - Therapeutic …, 2020 - journals.sagepub.com
Dimethyl fumarate (DMF) is approved for the treatment of relapsing-remitting multiple
sclerosis. It is unknown whether DMF or its primary metabolite monomethyl fumarate (MMF) …

[HTML][HTML] Monomethyl fumarate has better gastrointestinal tolerability profile compared with dimethyl fumarate

D Wynn, TW Lategan, TN Sprague… - Multiple sclerosis and …, 2020 - Elsevier
Background Monomethyl fumarate (MMF) is the pharmacologically active metabolite of
dimethyl fumarate (DMF). MMF formulated as Bafiertam™ 190 mg and DMF formulated as …

Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis

CB Burness, ED Deeks - CNS drugs, 2014 - Springer
Dimethyl fumarate (Tecfidera®) is a novel oral therapy that has recently been approved for
the treatment of relapsing forms of multiple sclerosis (MS) and relapsing-remitting MS …

Dimethyl fumarate: a review in relapsing-remitting MS

HA Blair - Drugs, 2019 - Springer
Dimethyl fumarate (Tecfidera®) is approved for the treatment of relapsing forms of multiple
sclerosis (MS). Based on evidence from the clinical trial and real-world settings, dimethyl …

No evidence for interactions of dimethylfumarate (DMF) and its main metabolite monomethylfumarate (MMF) with human cytochrome P450 (CYP) enzymes and the P …

J Aubets, JM Jansat, M Salva, VM Birks… - Pharmacology …, 2019 - Wiley Online Library
Dimethylfumarate (DMF) has long been used as part of a fixed combination of fumaric acid
esters (FAE) in some European countries and is now available as an oral monotherapy for …