Key relationships between non-invasive functional neuroimaging and the underlying neuronal activity

A Mishra, CN Hall, C Howarth… - … Transactions of the …, 2021 - royalsocietypublishing.org
Functional neuroimaging using MRI relies on measurements of blood oxygen level-
dependent (BOLD) signals from which inferences are made about the underlying neuronal …

Separating vascular and neuronal effects of age on fMRI BOLD signals

KA Tsvetanov, RNA Henson… - … Transactions of the …, 2021 - royalsocietypublishing.org
Accurate identification of brain function is necessary to understand the neurobiology of
cognitive ageing, and thereby promote well-being across the lifespan. A common tool used …

Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging

M D'Esposito, LY Deouell, A Gazzaley - Nature Reviews Neuroscience, 2003 - nature.com
Functional magnetic resonance imaging (fMRI) has rapidly emerged as a powerful tool for
studying brain function, despite the fact that it measures neuronal activity indirectly, through …

More than just summed neuronal activity: how multiple cell types shape the BOLD response

C Howarth, A Mishra, CN Hall - … Transactions of the …, 2021 - royalsocietypublishing.org
Functional neuroimaging techniques are widely applied to investigations of human cognition
and disease. The most commonly used among these is blood oxygen level-dependent …

Time-dependent spatial specificity of high-resolution fMRI: insights into mesoscopic neurovascular coupling

M Fukuda, AJ Poplawsky… - … Transactions of the …, 2021 - royalsocietypublishing.org
High-resolution functional magnetic resonance imaging (fMRI) is becoming increasingly
popular because of the growing availability of ultra-high magnetic fields which are capable …

Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience

CN Hall, C Howarth… - … Transactions of the …, 2016 - royalsocietypublishing.org
Cognitive neuroscience depends on the use of blood oxygenation level-dependent (BOLD)
functional magnetic resonance imaging (fMRI) to probe brain function. Although commonly …

Neuronal basis of non-invasive functional imaging: from microscopic neurovascular dynamics to BOLD fMRI

A Devor, DA Boas, GT Einevoll, RB Buxton… - Neural metabolism in …, 2012 - Springer
With the growing recognition of the complexity of neurovascular coupling, research has
focused on the “neurovascular unit”, a close association between neurons, astrocytes and …

Rude mechanicals in brain haemodynamics: non-neural actors that influence blood flow

A Das, K Murphy, PJ Drew - … Transactions of the Royal …, 2021 - royalsocietypublishing.org
Fluctuations in blood oxygenation and flow are widely used to infer brain activity during
resting-state functional magnetic resonance imaging (fMRI). However, there are strong …

The underpinnings of the BOLD functional magnetic resonance imaging signal

NK Logothetis - Journal of Neuroscience, 2003 - Soc Neuroscience
The good coverage and high resolution afforded by functional magnetic resonance imaging
(fMRI) make it an excellent tool for the noninvasive imaging of the human brain. Equally …

Quantitative functional MRI: concepts, issues and future challenges

GB Pike - Neuroimage, 2012 - Elsevier
Since its inception 20years ago, functional magnetic resonance imaging (fMRI) of the human
brain based on the blood oxygenation level dependent (BOLD) contrast phenomenon has …