Metastasis-associated protein 1-mediated antitumor and anticancer activity of dietary stilbenes for prostate cancer chemoprevention and therapy

AS Levenson - Seminars in cancer biology, 2022 - Elsevier
Dietary bioactive polyphenols that demonstrate beneficial biological functions including
antioxidant, anti-inflammatory, and anticancer activity hold immense promise as effective …

[HTML][HTML] Dietary pterostilbene is a novel MTA1-targeted chemopreventive and therapeutic agent in prostate cancer

S Dhar, A Kumar, L Zhang, AM Rimando, JM Lage… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Overexpression of the epigenetic modifier metastasis-associated protein 1 (MTA1) is
associated with aggressive human prostate cancer. The purpose of this study was to …

Mta1-dependent anticancer activity of gnetin c in prostate cancer

A Kumar, K Dholakia, G Sikorska, LA Martinez… - Nutrients, 2019 - mdpi.com
The overexpression of metastasis-associated protein 1 (MTA1) in prostate cancer (PCa)
contributes to tumor aggressiveness and metastasis. We have reported the inhibition of …

Dietary pterostilbene for MTA1-targeted interception in high-risk premalignant prostate cancer

R Hemani, I Patel, N Inamdar, G Campanelli… - Cancer Prevention …, 2022 - AACR
Prostate cancer remains one of the most prevalent cancers in aging men. Active surveillance
subpopulation of patients with prostate cancer includes men with varying cancer risk …

Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer

K Li, SJ Dias, AM Rimando, S Dhar, CS Mizuno… - PloS one, 2013 - journals.plos.org
The development of natural product agents with targeted strategies holds promise for
enhanced anticancer therapy with reduced drug-associated side effects. Resveratrol found …

In vitro anticancer properties of table grape powder extract (GPE) in prostate cancer

A Kumar, M D'silva, K Dholakia, AS Levenson - Nutrients, 2018 - mdpi.com
Although the link between diet and cancer is complex, epidemiological data confirm that diet
is a risk factor for prostate cancer and indicate a reduced prostate cancer incidence …

Targeting MTA1/HIF‐1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression

NA Butt, A Kumar, S Dhar, AM Rimando… - Cancer …, 2017 - Wiley Online Library
The metastasis‐associated protein 1 (MTA 1)/histone deacetylase (HDAC) unit is a cancer
progression‐related epigenetic regulator, which is overexpressed in hormone‐refractory …

Epigenetic potential of resveratrol and analogs in preclinical models of prostate cancer

A Kumar, S Dhar, AM Rimando, JM Lage… - Annals of the New …, 2015 - Wiley Online Library
Lifestyle, particularly diet, is a risk factor for prostate cancer. Dietary polyphenols such as
resveratrol possess anticancer properties and therefore have chemopreventive and …

[HTML][HTML] Silencing of METTL3 effectively hinders invasion and metastasis of prostate cancer cells

Y Chen, C Pan, X Wang, D Xu, Y Ma, J Hu, P Chen… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Since primary prostate cancer (PCa) can advance to the life-threatening
metastatic PCa, exploring the molecular mechanisms underlying PCa metastasis is crucial …

Therapeutic potential of gnetin C in prostate cancer: A pre-clinical study

K Gadkari, U Kolhatkar, R Hemani, G Campanelli… - Nutrients, 2020 - mdpi.com
Natural stilbenes have gained significant attention in the scientific community owing to their
potential anticancer effects against prostate cancer. We recently reported that Gnetin C, a …