Malignant brain tumors remain uniformly fatal, even with the best-to-date treatment. For
Glioblastoma (GBM), the most severe form of brain cancer in adults, the median overall …

The high mortality and poor clinical prognosis of glioblastoma multiforme (GBM) are
concerns for many GBM patients as well as clinicians and researchers. The lack of a …

Background Historically, creating patient-derived models of lower-grade glioma (LGG) has
been challenging, contributing to few experimental platforms that support laboratory-based …

Simple Summary Glioblastoma is the most lethal primary adult brain tumor. The great
number of mutations involved and the aggressiveness of glioblastoma render this type of …

Glioblastomas exhibit vast inter-and intra-tumoral heterogeneity, complicating the
development of effective therapeutic strategies. Current in vitro models are limited in …

Glioblastoma, a grade IV astrocytoma, is regarded as the most aggressive primary brain
tumour with an overall median survival of 16.0 months following the standard treatment …

Glioblastomas (GBMs) are the brain tumors with the highest malignancy and poorest
prognoses. GBM is characterized by high heterogeneity and resistance to drug treatment …

The emergence of three-dimensional human organoids has opened the door for the
development of patient-derived cancer organoid (PDO) models, which closely recapitulate …

Glioblastoma (GBM) remains a fatal diagnosis despite the current standard of care of
maximal surgical resection, radiation, and temozolomide (TMZ) therapy. One aspect that …

Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …