Regulatory gene networks and signaling pathways from primary osteoarthritis and Kashin–Beck disease, an endemic osteoarthritis, identified by three analysis …
S Wang, C Duan, F Zhang, W Ma, X Guo - Gene, 2013 - Elsevier
Three new software systems, Ingenuity pathway analysis (IPA, TranscriptomeBrowser and
MetaCore, were compared by analyzing chondrocyte microarray data of Kashin–Beck …
MetaCore, were compared by analyzing chondrocyte microarray data of Kashin–Beck …
Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment response in an endemic arthritis, Kashin-Beck disease
B Cheng, C Wu, W Wei, H Niu, Y Wen, C Li… - Bone & Joint …, 2024 - boneandjoint.org.uk
Identification of cell-specific epigenetic patterns associated with chondroitin sulfate treatment
response in an endemic arthrit Page 1 Identification of cell-specific epigenetic patterns …
response in an endemic arthrit Page 1 Identification of cell-specific epigenetic patterns …
DNA methylation and noncoding RNA in OA: Recent findings and methodological advances
V Izda, J Martin, C Sturdy, MA Jeffries - Osteoarthritis and cartilage open, 2021 - Elsevier
Introduction Osteoarthritis (OA) is a chronic musculoskeletal disease characterized by
progressive loss of joint function. Historically, it has been characterized as a disease caused …
progressive loss of joint function. Historically, it has been characterized as a disease caused …
Identification of DNA methylation-regulated differentially expressed genes in RA by integrated analysis of DNA methylation and RNA-Seq data
R Zhang, C Chang, Y Jin, LX Xu, P Jiang, K Wei… - Journal of Translational …, 2022 - Springer
Objective To identify novel DNA methylation-regulated differentially expressed genes
(MeDEGs) in RA by integrated analysis of DNA methylation and RNA-Seq data. Methods …
(MeDEGs) in RA by integrated analysis of DNA methylation and RNA-Seq data. Methods …
Tissue-specific methylation biosignatures for monitoring diseases: an in silico approach
Tissue-specific gene methylation events are key to the pathogenesis of several diseases
and can be utilized for diagnosis and monitoring. Here, we established an in silico pipeline …
and can be utilized for diagnosis and monitoring. Here, we established an in silico pipeline …
Mediation of the Same Epigenetic and Transcriptional Effect by Independent Osteoarthritis Risk–Conferring Alleles on a Shared Target Gene, COLGALT2
YS Kehayova, JM Wilkinson, SJ Rice… - Arthritis & …, 2023 - Wiley Online Library
Objective Over 100 DNA variants have been associated with osteoarthritis (OA), including
rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 …
rs1046934, located within a linkage disequilibrium block encompassing part of COLGALT2 …
A preliminary analysis of microRNA profiles in the subchondral bone between Kashin-Beck disease and primary knee osteoarthritis
GH Zhao, L Yang, MJ Lammi, X Guo - Clinical rheumatology, 2019 - Springer
Abstract Introduction Kashin-Beck disease (KBD) is a chronic osteochondral disorder
primarily associated with cartilage degeneration. The bone texture structure in KBD was also …
primarily associated with cartilage degeneration. The bone texture structure in KBD was also …
The epigenomic landscape in osteoarthritis
TC Simon, MA Jeffries - Current rheumatology reports, 2017 - Springer
Abstract Purpose of Review Epigenomics has emerged as a key player in our rapidly
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
evolving understanding of osteoarthritis. Historical studies implicated epigenetic alterations …
Genome‐wide study identifies the regulatory gene networks and signaling pathways from chondrocyte and peripheral blood monocyte of K ashin–B eck disease
S Wang, X Guo, W Wang, S Wang - Genes to Cells, 2012 - Wiley Online Library
This investigation was designed to unravel gene networks in K ashin–B eck disease (KBD)
and better identify target genes of KBD for gene therapy development. RNA was isolated …
and better identify target genes of KBD for gene therapy development. RNA was isolated …
[HTML][HTML] Systemic analysis of osteoblast-specific DNA methylation marks reveals novel epigenetic basis of osteoblast differentiation
F Yu, H Shen, HW Deng - Bone Reports, 2017 - Elsevier
DNA methylation is an important epigenetic modification that contributes to the lineage
commitment and specific functions of different cell types. In this study, we compared …
commitment and specific functions of different cell types. In this study, we compared …