Understanding the immunopathogenesis of autoimmune and inflammatory diseases is a
prerequisite for specific and effective therapeutical intervention. This review focuses on …

In recent years considerable headway has been made on understanding the mechanisms
underlying inflammatory diseases of the eye. This includes the role of the innate vs. adaptive …

PURPOSE. The purpose of this study was to determine if autoantibodies play a role in the
immunopathogenesis of experimental dry eye disease. METHODS. Dry eye was induced by …

The tear film, lacrimal glands, corneal and conjunctival epithelia and Meibomian glands
work together as a lacrimal functional unit (LFU) to preserve the integrity and function of the …

Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of
blindness worldwide. On the basis of aetiology, disease can be classified as infectious or …

Rheumatoid arthritis (RA), the most common autoimmune disorder associated with dry eye
syndrome, is also associated with sight-threatening ocular diseases such as peripheral …

Autoimmune uveitis is a group of HLA-associated inflammatory diseases of the eye, which
can cause blindness. Patients exhibit cellular and humoral responses to immunologically …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

Uveitis of putative autoimmune origin comprises a heterogeneous group of sight-threatening
diseases prevalent in the US and worldwide. Several animal models, representing various …

Dry eye disease (DED) is a prevalent public health concern that affects up to 30% of adults
and is particularly chronic and severe in the elderly. Two interconnected mechanisms cause …