Bone regeneration is a complex process sequentially regulated by multiple cytokines at
different stages. Vascular endothelial growth factor-A (VEGF-A) and bone morphogenetic …

Multiple growth factors can be administered to mimic the natural process of bone healing in
bone tissue engineering. We investigated the effects of sequential release of bone …

To effectively harness the great potential of stem cells, we designed a dual growth factor
delivery system for the application toward stem cell differentiation into specific lineages. This …

Core–shell polymer spheres of submicron diameter are a promising vehicle for sequential
delivery of angiogenic and osteogenic growth factors to bone defect sites, to simulate the …

Osteoinductive biomaterials are helpful for the therapy of large bone defects and provide an
alternative to autogenous bone and allografts. Recently, multiple growth factors are …

Growth factors (GFs) are very critical in stem cell differentiation and tissue regeneration.
Therefore GF delivery carriers have been a major subject in tissue engineering research. In …

Bone tissue regeneration may be more effectively administrated by controlled release of
multiple biofactors, given that bone healing comprises a cascade of biological events …

Growth factors (GFs) are major biochemical cues for tissue regeneration. Herein, a novel
dual GF delivery system is designed composed of poly (lactic‐co‐glycolic acid)(PLGA) …

Rapid new microvascular network induction was critical for bone regeneration, which
required the spatiotemporal delivery of growth factors and transplantation of endothelial …

Reconstruction of large bone defects is limited by insufficient vascularization and slow bone
regeneration. The objective of this work was to investigate the effect of spatial and temporal …