6051 Background: Patients with HD may require drug dose modification based on the
severity of HD. HD is often assessed using CP criteria, the use of which is advocated by the …

Guidance from the US Food and Drug Administration (FDA) and the European Medicines
Agency recommends using Child‐Pugh classification for pharmacokinetic evaluation in …

Abstract Purpose: The NCI Cancer Therapy Evaluation Program sponsors hepatic
dysfunction phase I clinical trials (HDCT) and phase 1 clinical trials (P1CT) to determine safe …

The difficult problem faced by multiple generation of practicing physicians is determining the
cause of abnormal liver function tests in cancer patients on chemotherapy. Hepatotoxicity …

Objective: Functional hepatic reserve is important when considering sequential tyrosine
kinase inhibitor (TKI) therapy for patients with advanced hepatocellular carcinoma (HCC) …

Purpose Most patients with hepatocellular carcinoma (HCC) have associated chronic liver
disease, the severity of which is currently assessed by the Child-Pugh (CP) grade. In this …

The liver is fundamentally important in drug metabolism. In oncology, the astute clinician
must not only understand the meaning and limitations of commonly ordered liver …

Advanced cancer in the setting of liver dysfunction poses a dilemma for physicians, as many
cancer chemotherapeutic agents undergo hepatic metabolism. Most cytotoxic drugs have a …

The liver has a key role in the metabolism (ie, inactivation or activation) of many commonly
used anticancer agents—cytotoxics or new biological agents. Therefore, assessment of liver …

There is no established treatment for patients with advanced hepatocellular carcinoma
(HCC) with Child–Pugh class B cirrhosis. The aim of the present study was to assess the …