Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell
hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to …

Background: Intracellular calcium and proton concentrations are important factors for
activating human sperm. Calcium ion (Ca 2+) enters sperm through voltage-dependent …

The effect of verapamil, a calcium channel blocker, on male fertility in terms of ion channel
and miRNA gene expressions in testis/spermatozoa was evaluated in this study. Rats were …

Recently, more and more studies have discovered that some diseases result from gene
defect and functional variation of ion channels, which are called ion passage diseases or ion …

Catsper1 is a voltage-gated calcium channel located in the plasma membrane of the sperm
tail and is necessary for sperm motility and fertility in mice. We here examine the …

Objective To explore the functional implications of a homozygous CATSPER 2 (cation
channel for sperm) deletion within the acrosome reaction pathway during fertilization in 2 …

Catsper is a Ca 2+ permeable channel required for sperm hyperactivation. In spite of its
central role in male fertility, the transcriptional mechanisms that regulate Catsper1 …

Propose: CatSper protein channels are responsible for the entry of Ca2+ into sperm cells.
These proteins play an important role in motility and male fertility. So it is important to find out …

There is a global need for an ideal method of male contraception. However, the
development of male contraceptives has not been well successful. Research on sperm …

Among several candidate Ca 2+ entry channels in sperm, only CatSper1 and CatSper2 are
known to have required roles in male fertility. Past work with CatSper1 null sperm indicates …