Elevations of sperm Ca2+ seem to be responsible for an asymmetric form of motility called
hyperactivation, which is first seen near the time of fertilization. The mechanism by which …

Nature. Two groups using patch clamping techniques on human sperm have solved a
mystery about the sperm cell that has puzzled both andrologists and those involved in …

Study question Is a loss of CatSper function in sperm a common cause of unexplained male
infertility? Summary answer Loss of CatSper function leads to similar infertility phenotypes in …

Whole-cell voltage clamp of mammalian spermatozoa was first achieved in 2006. This
technical advance, combined with genetic deletion strategies, makes unambiguous …

Highlights•In vivo, a successful fertilization is dependent on sperm hyperactivated motility.•
Hyperactivation is triggered by a calcium influx into flagellum via sperm-specific calcium …

The main cation/calcium channel of spermatozoa (CatSper), first identified in 2001, has
been thoroughly studied to elucidate its composition and function, while its distribution …

Spermatozoa and neurones share similar membrane characteristics and features.
Associations of multiple polymorphisms traditionally related to neurotransmission were …

Cation channel of sperm 1 (CATSPER1) is a unique sperm cation channel protein, and
essential for sperm function and male fertility. CATSPER1 exclusively expresses in meiotic …

The ion channels in sperm tail play an important role in triggering key physiological
reactions, eg, progressive motility, hyperactivation, required for successful fertilization …

In 2001, two groups independently reported different components of a novel Ca 2+ channel
named CatSper, which is expressed only in the testis and localized in the sperm flagellum …