Bisbenzylisoquinoline Alkaloids of Cissampelos Sympodialis With in Vitro Antiviral Activity Against Zika Virus

PG da Silva, AH Fonseca, MP Ribeiro… - Frontiers in …, 2021 - frontiersin.org
In search of new antiviral compounds against Zika virus we conducted a bioassay-guided
fractionation of bisbenzyilisoquinoline alkaloids isolated from Cissampelos sympodialis …

Tri- and Diterpenoids from Stillingia loranthacea as Inhibitors of Zika Virus Replication

LS Abreu, YM do Nascimento, RS Costa… - Journal of natural …, 2019 - ACS Publications
This study represents the first phytochemical analysis of Stillingia loranthacea (S.
loranthacea) and describes new terpenoids obtained from the root bark of this species. The …

Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach

AC Ferraz, PWP Gomes, MB da Silva Menegatto… - Phytomedicine, 2024 - Elsevier
Background Zika virus (ZIKV) is an emerging arbovirus that in recent years has been
associated with cases of severe neurological disorders, such as microcephaly in newborns …

Natural products as Zika antivirals

YD Fong, JJH Chu - Medicinal research reviews, 2022 - Wiley Online Library
Zika virus (ZIKV) is an arbovirus belonging to the flavivirus genus and is transmitted in
Aedes mosquito vectors. Since its discovery in humans in 1952 in Uganda, ZIKV has been …

The flavonoid isoquercitrin precludes initiation of Zika virus infection in human cells

A Gaudry, S Bos, W Viranaicken, M Roche… - International journal of …, 2018 - mdpi.com
The medical importance of Zika virus (ZIKV) was fully highlighted during the recent
epidemics in South Pacific islands and Americas due to ZIKV association with severe …

Benzimidazole derivatives as novel zika virus inhibitors

BTB Hue, PH Nguyen, TQ De, M Van Hieu… - …, 2020 - Wiley Online Library
We have synthesized 50 benzimidazole (BMZ) derivatives with 1, 2‐phenylenediamines and
aromatic aldehydes under mild oxidation conditions by using inexpensive, nontoxic …

Identification of ascomycin against Zika virus infection through screening of natural product library

L Zhou, J Zhou, T Chen, X Chi, X Liu, S Pan, W Chen… - Antiviral Research, 2021 - Elsevier
Zika virus (ZIKV) infection could lead to Guillain-Barré syndrome in adults and microcephaly
in the newborns from infected pregnant women. To date, there is no specific drug for the …

Anti–Zika Virus Activity and Isolation of Flavonoids from Ethanol Extracts of Curatella americana L. Leaves

LDA Lima, ACC Reis, JAC Sousa, GM Valente… - Molecules, 2023 - mdpi.com
The ethnomedicinal plant Curatella americana L.(Dilleniaceae) is a common shrub in the
Brazilian Cerrado, whose ethanolic extract showed significant in vitro anti–Zika virus activity …

Antiviral effect of the seaweed Osmundaria obtusiloba against the Zika virus

CC Cirne-Santos, C de Souza Barros… - Journal of Medicinal …, 2018 - academicjournals.org
Zika virus (ZIKV), a mosquito-borne member of the family Flaviviridae, is a human pathogen
of global significance. Recently, ZIKV, has become a public health problem with increases in …

Identification of novel natural products as effective and broad-spectrum anti-Zika virus inhibitors

Y Gao, W Tai, N Wang, X Li, S Jiang, AK Debnath, L Du… - Viruses, 2019 - mdpi.com
Zika virus (ZIKV) infection during pregnancy leads to severe congenital Zika syndrome,
which includes microcephaly and other neurological malformations. No therapeutic agents …