Summary Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that …

Innate lymphoid cells (ILCs) and CD4+ T cells produce IL-22, which is critical for intestinal
immunity. The microbiota is central to IL-22 production in the intestines; however, the factors …

T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how
microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short …

TH17 cells are a lineage of CD4+ T cells that are critical for host defense and autoimmunity
by expressing the cytokines IL-17A, IL-17F, and IL-22. A feature of TH17 cells at steady state …

The gut microbiota is essential for the maintenance of intestinal immune homeostasis and is
responsible for breaking down dietary fiber into short-chain fatty acids (SCFAs). Butyrate, the …

A high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in
response to changes in the intestinal microbiota through as-yet-unknown mechanisms …

The microbiota control regional immunity using mechanisms such as inducing IL-17A-
producing γδ T (γδT-17) cells in various tissues. However, little is known regarding hepatic …

The requirements for in vivo steady state differentiation of IL-17-producing T-helper (Th17)
cells, which are potent inflammation effectors, remain obscure. We report that Th17 cell …

Background How the gut microbiota regulates intestinal homeostasis is not completely clear.
Gut microbiota metabolite short-chain fatty acids (SCFAs) have been reported to regulate T …

The role of the microbiota in the development and function of γδ T cells—a T cell subset
characterized by a T cell receptor composed of one γ-chain and one δ-chain—has been …