Inhibiting RhoA-subfamily GTPases by C3 transferase is widely recognized as a prospective
strategy to enhance axonal regeneration. When C3 transferase is administered for treating …

Peripheral nerve injury triggers the activation of RhoA in spinal motor and peripheral
sensory neurons. RhoA activates a number of effector proteins including the Rho-associated …

RhoA is a small GTPase that regulates many functions of mammalian cells via actin
reorganization. Lots of studies uncovered that its activation acts as a major negative …

Our previous studies indicated that RhoA knockdown or inhibition could alleviate the
proliferation, migration, and differentiation of Schwann cells. However, the role of RhoA in …

Rho-associated Kinase (ROCK) has been identified as an important regulator of proliferation
and cell cycle progression in a number of cell types. Although its effects on astrocyte …

Myelin-associated inhibitors limit axonal regeneration in the injured brain and spinal cord. A
common target of many neurite outgrowth inhibitors is the Rho family of small GTPases …

RhoA-GTPase (RhoA) is widely regarded as a key molecular switch to inhibit neurite
outgrowth by rigidifying the actin cytoskeleton. However, during neurite outgrowth, whether …

Neurons in the adult mammalian CNS do not spontaneously regenerate axons after injury
due to CNS myelin and other inhibitory factors. Previous studies have showed that inhibition …

Background Plenty of macrophages are recruited to the injured nerve to play key roles in the
immunoreaction and engulf the debris of degenerated axons and myelin during Wallerian …

Several molecules inhibit axonal growth cones and may account for the failure of central
nervous system regeneration, including myelin proteins and various chondroitan sulfate …