Amyloid plaques and neurofibrillary tangles are the key pathological features of Alzheimer's
disease (AD). Studies have shown that C-reactive protein (CRP) increases during …

Recent studies have demonstrated that activation of the Rho-associated kinase (ROCK)
pathway participates in the dopaminergic neuron degeneration and possibly in Parkinson's …

Background: Spinal cord injury (SCI) is a challenge worldwide, but there are no effective
treatments or therapeutic methods in the clinic. Recent studies have shown that type I …

Neurite plasticity is a critical aspect of brain functional recovery after stroke. Emerging data
suggest that Ras-related C3 botulinum toxin substrate 1 (Rac1) plays a central role in axonal …

Y-27632 is known as a selective Rho-associated coiled coil-forming kinase (ROCK)
inhibitor. Y-27632 has been shown to induce neurite outgrowth in several neuronal cells …

Spontaneous axonal regeneration of neurons does not occur after spinal cord injury
because of inhibition by myelin and other inhibitory factors. Studies have demonstrated that …

It is currently thought that treatment for spinal cord injury (SCI) will involve a combined
pharmacological and biological approach; however, testing their efficacy in animal models …

Molecular cues, such as netrin 1, guide axons by influencing growth cone motility. Rho
GTPases are a family of intracellular proteins that regulate the cytoskeleton, substrate …

Peripheral nerve injury triggers the activation of the small GTPase RhoA in spinal motor and
peripheral sensory neurons. C3 transferase, an exoenzyme produced by Clostridium …

Introduction: The aim of the presented study was to investigate nerve regeneration after
application of C3‐Toxin, a Rho‐GTPase inhibitor and to correlate morphometry …