Objectives: To determine the impact of positive end-expiratory pressure during mechanical
ventilation with and without spontaneous breathing activity on regional lung inflammation in …

Objectives: To assess the effects of different levels of spontaneous breathing during biphasic
positive airway pressure/airway pressure release ventilation on lung function and injury in …

Objective: It is known that ventilator-induced lung injury causes increased pulmonary
inflammation. It has been suggested that one of the underlying mechanisms may be strain …

We examined the hypothesis that injurious ventilatory strategies (large tidal volume [Vt]
and/or low positive end-expiratory pressure [PEEP]) would increase release of inflammatory …

Objective: To investigate the effects of low and high levels of positive end-expiratory
pressure (PEEP), without recruitment maneuvers, during lung protective ventilation in an …

Objective: Volutrauma and atelectrauma promote ventilator-induced lung injury, but their
relative contribution to inflammation in ventilator-induced lung injury is not well established …

Objective Previous animal studies have shown that certain modes of mechanical ventilation
(MV) can injure the lungs. Most of those studies were performed with models that differ from …

Background Lung injury is often studied without consideration for pathologic changes in the
chest wall. In order to reduce the incidence of lung injury using preemptive mechanical …

Objective: The early phase of acute respiratory distress syndrome (ARDS) is characterized
by impaired respiratory mechanics, ventilation-perfusion mismatch, and severe hypoxemia …

Background In moderate acute respiratory distress syndrome (ARDS) several studies
support the usage of assisted spontaneous breathing modes. Only limited data, however …