Muscle-specific adaptations, impaired oxidative capacity and maintenance of contractile function characterize diet-induced obese mouse skeletal muscle

KE Shortreed, MP Krause, JH Huang, D Dhanani… - PloS one, 2009 - journals.plos.org
Background The effects of diet-induced obesity on skeletal muscle function are largely
unknown, particularly as it relates to changes in oxidative metabolism and morphology …

Early oxidative shifts in mouse skeletal muscle morphology with high‐fat diet consumption do not lead to functional improvements

MM Thomas, KE Trajcevski, SK Coleman… - Physiological …, 2014 - Wiley Online Library
Short‐term consumption of a high‐fat diet (HFD) can result in an oxidative shift in adult
skeletal muscle. However, the impact of HFD on young, growing muscle is largely unknown …

Enhanced lipid oxidation and maintenance of muscle insulin sensitivity despite glucose intolerance in a diet-induced obesity mouse model

KE Trajcevski, HM O'Neill, DC Wang, MM Thomas… - PLoS …, 2013 - journals.plos.org
Background Diet-induced obesity is a rising health concern which can lead to the
development of glucose intolerance and muscle insulin resistance and, ultimately, type II …

Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast-versus slow-twitch muscle contractile function in C57BL/6J …

J Ciapaite, SA van den Berg, SM Houten… - The Journal of nutritional …, 2015 - Elsevier
High-fat diets (HFDs) have been shown to interfere with skeletal muscle energy metabolism
and cause peripheral insulin resistance. However, understanding of HFD impact on skeletal …

Altered lipid metabolism impairs skeletal muscle force in young rats submitted to a short-term high-fat diet

DE Andrich, Y Ou, L Melbouci… - Frontiers in …, 2018 - frontiersin.org
Obesity and ensuing disorders are increasingly prevalent in young populations. Prolonged
exposure to high-fat diets (HFD) and excessive lipid accumulation were recently suggested …

Short-term high fat-feeding results in morphological and metabolic adaptations in the skeletal muscle of C57BL/6J mice

J de Wilde, R Mohren, S van den Berg… - Physiological …, 2008 - journals.physiology.org
The prevalence of the metabolic syndrome (MS) is rapidly increasing all over the world.
Consequently, there is an urgent need for more effective intervention strategies. Both animal …

The effects of diet composition and chronic obesity on muscle growth and function

LGO de Sousa, AG Marshall… - Journal of Applied …, 2021 - journals.physiology.org
Diet-induced obesity (DIO) is associated with glucose intolerance, insulin resistance (IR),
and an increase in intramyocellular lipids (IMCL), which may lead to disturbances in glucose …

Acute and chronic changes in rat soleus muscle after high‐fat high‐sucrose diet

KH Collins, DA Hart, IC Smith, AM Issler… - Physiological …, 2017 - Wiley Online Library
The effects of obesity on different musculoskeletal tissues are not well understood. The
glycolytic quadriceps muscles are compromised with obesity, but due to its high oxidative …

The impact of a high-fat diet in mice is dependent on duration and age, and differs between muscles

GAM Messa, M Piasecki, J Hurst, C Hill… - Journal of …, 2020 - journals.biologists.com
Prolonged high-fat diets (HFDs) can cause intramyocellular lipid (IMCL) accumulation that
may negatively affect muscle function. We investigated the duration of a HFD required to …

Distinct skeletal muscle fiber characteristics and gene expression in diet-sensitive versus diet-resistant obesity

MF Gerrits, S Ghosh, N Kavaslar, B Hill, A Tour… - Journal of lipid …, 2010 - ASBMB
Inter-individual variability in weight gain and loss under energy surfeit and deficit conditions,
respectively, are well recognized but poorly understood phenomena. We documented …