BACKGROUND: Pain and depression are highly prevalent symptoms in cancer patients.
They tend to occur simultaneously and affect each other and share biological pathways and …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

Background: Pain is one of the main protests of inflammatory diseases, hence,
understanding the mechanisms which involved in the induction and persistence of pain is …

The mechanisms associated with diabetes‑induced neuropathic pain are complex and
poorly understood. In order to understand the involvement of spinal microglia activity in …

Background and Objectives Minocycline is a second-generation tetracycline with multiple
biological effects, including inhibition of microglial activation. Recently, microglial activation …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

Background: Evidence indicates that neuropathic pain pathogenesis is not confined to
changes in the activity of neuronal systems but involves interactions between neurons …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …

Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …

Cancer pain, especially bone cancer pain, is a pain state often caused by inflammation or
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …