BACKGROUND: Pain and depression are highly prevalent symptoms in cancer patients.
They tend to occur simultaneously and affect each other and share biological pathways and …

Aim: To investigate the mechanisms underlying the anti-nociceptive effect of minocycline on
bone cancer pain (BCP) in rats. Methods: A rat model of BCP was established by inoculating …

Background and Objectives Minocycline is a second-generation tetracycline with multiple
biological effects, including inhibition of microglial activation. Recently, microglial activation …

Background: Pain is one of the main protests of inflammatory diseases, hence,
understanding the mechanisms which involved in the induction and persistence of pain is …

There is a paucity of data on the role of microglia and neuroinflammatory processes in the
association between chronic pain and depression. The current study examined the effect of …

We have previously demonstrated that activation of p38 mitogen-activated protein kinase
(p38 MAPK) in the spinal microglia mediates morphine antinociceptive tolerance …

Neuroinflammatory response in spinal dorsal horn has been demonstrated to be a critical
factor in oxaliplatin-induced pain. Melatonin has been shown to have anti-inflammatory and …

Cancer pain, especially bone cancer pain, is a pain state often caused by inflammation or
dysfunctional nerves. Moreover, in the management of cancer pain, opioid especially …

Although it is known that isoflurane exposure or surgery leads to post‐operative cognitive
dysfunction in aged rodents, there are few clinical interventions and treatments available to …

We previously demonstrated that intrathecal IL‐1β caused thermal hyperalgesia in rats. This
study was conducted to examine the effects and cellular mechanisms of glial inhibitors on IL …