Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer
pain. Spinal glial cells play a critical role in maintenance of cancer pain by releasing …

Oxaliplatin, a platinum-based chemotherapeutic agent, has become a standard treatment for
advanced colorectal cancer. The dose-limiting toxicity of this compound is the development …

Our previous study indicated that coadministration of tramadol and minocycline exerted
synergistic effects on spinal nerve ligation (SNL)-induced neuropathic mechanical allodynia …

Background Chemotherapy-induced peripheral neuropathy is a major side effect of anti-
cancer drugs, and our knowledge of its mechanisms is lacking. Several models for …

Background Pain is one of the most common and distressing symptoms suffered by patients
with progression of cancer; however, the mechanisms responsible for hyperalgesia are not …

Background: Tumor necrosis factor α (TNF-α) may have a pivotal role in the genesis of
mechanical allodynia and thermal hyperalgesia during inflammatory and neuropathic pain …

Background We previously reported a correlation between small doses of oxaliplatin
penetrating onto the spinal cord and acute pain after chemotherapy. Here, we propose that …

Cancer-induced bone pain (CIBP) is a challenging medical problem that considerably
influences cancer patients' quality of life. Currently, few treatments have been developed to …

Methotrexate (MTX) is a well-known cytostatic agent used in adjuvant chemotherapy for
breast cancer, that has neurological side effects, including depression and cognitive …

Background Sleep deprivation (SD) leads to cognitive impairment. Neuroinflammation could
be a significant contributing factor in the same. An increase in regional brain pro …