Biological processes such as cellular differentiation or response to environmental stimuli
require gene expression adaptations. Such plastic remodeling is achieved by the …

Cell-autonomous oscillation in clock gene expression drives circadian rhythms. The
development of comprehensive analytical techniques, such as bioinformatics and ChIP …

Circadian clocks (~ 24h) are responsible for daily physiological, metabolic and behavioral
changes. Central to these oscillations is the regulation of gene transcription. Previous …

Circadian rhythms are fundamental properties of most cells in our body. However, early
embryos and germline cells do not show circadian rhythms. Recent studies have revealed …

The molecular players of circadian clock oscillation have been identified and extensively
characterized. The epigenetic mechanisms behind the circadian gene expression control …

Abstract Circadian (24-h) rhythms dictate almost everything we do, setting our clocks for
specific times of sleeping and eating, as well as optimal times for many other basic functions …

Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Highlights•Work on circadian period determination and output gene regulation are
reviewed.•Clock protein glycosylation, ubiquitylation and translation influence 24 hours …

Each day we perform a ritual: We sleep for∼ 8 h, awaken and rise, and∼ 16 h later, we
sleep again. This ritual is based on a temporal program that continues, although not …

The complexity of tissue-and day time-specific regulation of thousands of clock-controlled
genes (CCGs) suggests that many regulatory mechanisms contribute to the transcriptional …