The circadian system in higher organisms temporally orchestrates rhythmic changes in a
vast number of genes and gene products in different organs. Complex interactions between …

The molecular circadian clock orchestrates the daily cyclical expression of thousands of
genes. Disruption of this transcriptional program leads to a variety of pathologies, including …

Circadian (24h) clocks provide a source of internal timing in most living organisms. These
clocks keep time by using complex transcriptional/posttranslational feedback loops that are …

The circadian clock, an internal time-keeping system orchestrates 24-hour rhythms in
physiology and behavior by governing rhythmic transcription within cells. Astrocyte, the most …

The circadian clock is an endogenous molecular oscillator based on simple transcriptional,
translational, and post-translational feedback loops. Therefore it can be found in such …

Many aspects of mammalian physiology display circadian--or once daily--rhythms, such as
heart rate, blood pressure, activity levels, metabolism, and liver regeneration. These rhythms …

The mammalian circadian clock is based on a transcription–translation feedback loop
(TTFL) in which CLOCK and BMAL1 proteins act as transcriptional activators of …

The molecular mechanism of circadian clocks is complex: it involves many genes and
several interlocked positive and negative feedback loops. However mathematical models …

The circadian clock is a tightly regulated mechanism that has evolved in most organisms to
enable them to anticipate daily reoccurring changes in the environment. Expression analysis …