Hearing loss among the elderly correlates with diminished social, mental, and physical
health. Age-related cochlear cell death does occur, but growing anatomical evidence …

Exposure to loud sound can irreversibly damage or destroy peripheral auditory structures,
including the inner hair cells (IHCs) and outer hair cells (OHCs) of the cochlea and the spiral …

The occurrence of tinnitus can be linked to hearing loss in the majority of cases, but there is
nevertheless a large degree of unexplained heterogeneity in the relation between hearing …

Animal models of tinnitus require a behavioral correlate thereof. Various conditioned
response methods and gap-startle reflex methods are in use and the outcomes generally …

Recent work suggests that hair cells are not the most vulnerable elements in the inner ear;
rather, it is the synapses between hair cells and cochlear nerve terminals that degenerate …

Sound pressure fluctuations striking the ear are conveyed to the cochlea, where they vibrate
the basilar membrane on which sit hair cells, the mechanoreceptors of the inner ear …

Studies in multiple species, including in post-mortem human tissue, have shown that normal
aging and/or acoustic overexposure can lead to a significant loss of afferent synapses …

The cochlea is a delicate and complex structure designed to transduce sound into the
electrical activity of neurons. Damage to any of the components of the cochlea can result in …

The classic view of sensorineural hearing loss has been that the primary damage targets are
hair cells and that auditory nerve loss is typically secondary to hair cell degeneration …

Clinical audiometry has long focused on determining the detection thresholds for pure tones,
which depend on intact cochlear mechanics and hair cell function. Yet many listeners with …