Connexins and gap junctions play a crucial role during carcinogenesis. While diverse
regulatory systems have been shown to modulate their function, the influence of cell motility …

Tumour development is a process resulting from the disturbance of various cellular functions
including cell proliferation, adhesion and motility. While the role of these cell parameters in …

Impaired expression of connexins, the gap junction subunits that facilitate direct cell-cell
communication, have been implicated in prostate cancer growth. To elucidate the crucial …

BACKGROUND Gap junctional communication (GJC) has been implicated in the control of
cell proliferation. Numerous cancer cells show a decrease or loss of GJC compared to their …

Gap junctional intercellular communication (GJIC) as well as cell migration play an essential
role in the metastatic cascade of human tumors. We show a dependence of metastatogenic …

Tissue homeostasis is the result of a complex intercellular network controlling the behavior
of every cell for the survival of the whole organism. In mammalian tissues, cells do …

Formation of metastases negatively impacts the survival prognosis of cancer patients.
Globally, if the various steps involved in their formation are relatively well identified, the …

The formation of aqueous intercellular channels mediating gap junctional intercellular
coupling (GJIC) is a canonical function of connexins (Cx). In contrast, mechanisms of GJIC …

Background information. Motile activity of tumour cells is regarded as a critical factor
determining their metastatic potential. We have shown previously that contrary to the …

Simple Summary Connexins are proteins which comprise gap junctions in cells. These
junctions can directly connect neighboring cells and the cell interior with the extracellular …