Background PP‐007 is a polyethylene glycol (PEG) ylated bovine carboxyhemoglobin gas
transfer molecule with pleotropic cytoprotective effects, vasodilatation, plasma expansion …

Background PP-007 is a PEGylated bovine carboxyhemoglobin gas transfer molecule with
pleotropic cytoprotective effects, vasodilatation, plasma expansion and optimization of …

Introduction Despitehigh rates ofrecanalizationafter mechanical thrombectomy (MT), only 33–
71% of patients achieve functional independence at 90 days. Experimental ischemia …

Background Sanguinate, a bovine PEGylated carboxyhemoglobin-based oxygen carrier
with vasodilatory, oncotic and anti-inflammatory properties designed to release oxygen in …

Abstract Background Abnormal hemoglobin (Hb) levels lead to poorer outcomes in ischemic
stroke, though the mechanisms remain elusive. We aimed to study the role of Hb on imaging …

Introduction: Recent advancements in endovascular thrombectomy for large vessel acute
ischemic stroke (AIS) have achieved longer intervention time windows (16-24 h) and higher …

Background Peri-procedural blood loss and hemodilution occur in patients undergoing
mechanical thrombectomy (MT) for ischemic stroke; however, its relationships with …

Adjuvant neuroprotective therapies for acute ischemic stroke (AIS) have demonstrated
benefit in animal studies, albeit without human translation. We investigated the safety and …

Rationale: Oxygen is essential for cellular energy metabolism. Neurons are particularly
vulnerable to hypoxia. Increasing oxygen supply shortly after stroke onset could preserve …

BACKGROUND AND PURPOSE: High recanalization rates achieved with endovascular
procedures are not always followed by the expected clinical improvement. These time …