Approaches to improve therapeutic efficacy of biodegradable PLA/PLGA microspheres: a review

SL Bee, ZAA Hamid, M Mariatti, BH Yahaya… - Polymer …, 2018 - Taylor & Francis
This review aims to provide a comprehensive overview about various innovative strategies
that have been employed by recent researchers to overcome with the shortcomings …

Strategies for encapsulation of small hydrophilic and amphiphilic drugs in PLGA microspheres: state-of-the-art and challenges

F Ramazani, W Chen, CF van Nostrum, G Storm… - International journal of …, 2016 - Elsevier
Abstract Poly (lactide-co-glycolide)(PLGA) microspheres are efficient delivery systems for
controlled release of low molecular weight drugs as well as therapeutic macromolecules …

Recent advance in polymer based microspheric systems for controlled protein and peptide delivery

Y Yang, Q Chen, J Lin, Z Cai, G Liao… - Current medicinal …, 2019 - ingentaconnect.com
Sustained-release systems made by biodegradable polymers for protein and peptide drug
delivery have received considerable attention by academic researchers and major …

Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA

C Cai, S Mao, O Germershaus, A Schaper… - Journal of …, 2009 - Taylor & Francis
The aim of the present work was to understand the collaborative roles and the
comprehensive effects of polymer nature, morphology, drug distribution and release …

Synthesis and characterization of PLGA shell microcapsules containing aqueous cores prepared by internal phase separation

SR Abulateefeh, AM Alkilany - Aaps Pharmscitech, 2016 - Springer
The preparation of microcapsules consisting of poly (d, l-lactide-co-glycolide)(PLGA)
polymer shell and aqueous core is a clear challenge and hence has been rarely addressed …

PLGA/PLA-based long-acting injectable depot microspheres in clinical use: production and characterization overview for protein/peptide delivery

A Butreddy, RP Gaddam, N Kommineni… - International journal of …, 2021 - mdpi.com
Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide
(PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled …

Encapsulation and sustained release from biodegradable microcapsules made by emulsification/freeze drying and spray/freeze drying

W Yin, MZ Yates - Journal of colloid and interface science, 2009 - Elsevier
Hollow biodegradable poly (dl-lactide)(PLA) particles with porous shell walls were prepared
by freeze drying small droplets of PLA solution formed by emulsification or spraying. The …

Recent advances in the formulation of PLGA microparticles for controlled drug delivery

E Lagreca, V Onesto, C Di Natale, S La Manna… - Progress in …, 2020 - Springer
Polymeric microparticles (MPs) are recognized as very popular carriers to increase the
bioavailability and bio-distribution of both lipophilic and hydrophilic drugs. Among different …

Computer modeling assisted design of monodisperse PLGA microspheres with controlled porosity affords zero order release of an encapsulated macromolecule for 3 …

F Kazazi-Hyseni, M Landin, A Lathuile… - Pharmaceutical …, 2014 - Springer
Purpose The aim of this study was the development of poly (D, L-lactide-co-
glycolide)(PLGA) microspheres with controlled porosity, to obtain microspheres that afford …

A one-step electrospray-based technique for modulating morphology and surface properties of poly(lactide-co-glycolide) microparticles using Pluronics®

A Seth, DS Katti - International journal of nanomedicine, 2012 - Taylor & Francis
The influence of morphology and surface properties on the therapeutic efficacy of
degradable polymeric microparticles has not been well understood. One of the primary …