Partial protection against chlamydial reproductive tract infection by a recombinant major outer membrane protein/CpG/cholera toxin intranasal vaccine in the guinea …

DW Andrew, LM Hafner, KW Beagley… - Journal of reproductive …, 2011 - Elsevier
Chlamydia trachomatis is a major cause of sexually transmitted diseases worldwide. There
is currently no vaccine to protect against chlamydial infection of the female reproductive …

[HTML][HTML] A vaccine formulated with a combination of TLR-2 and TLR-9 adjuvants and the recombinant major outer membrane protein elicits a robust immune response …

C Cheng, S Pal, D Tifrea, Z Jia, LM de la Maza - Microbes and infection, 2014 - Elsevier
Chlamydia trachomatis is the most common sexually transmitted bacterial pathogen in the
World and there is a need for a vaccine. To enhance the immunogenicity of a vaccine …

Immunization with the Chlamydia trachomatis Mouse Pneumonitis Major Outer Membrane Protein Can Elicit a Protective Immune Response against a Genital …

S Pal, I Theodor, EM Peterson… - Infection and …, 2001 - Am Soc Microbiol
Infertility, ectopic pregnancy, and chronic abdominal pain are frequent complications of
genital infections with Chlamydia trachomatis. In an attempt to produce a vaccine to protect …

CD4+ T Cells and Antibody Are Required for Optimal Major Outer Membrane Protein Vaccine-Induced Immunity to Chlamydia muridarum Genital Infection

CM Farris, SG Morrison, RP Morrison - Infection and immunity, 2010 - Am Soc Microbiol
Despite effective antimicrobial chemotherapy, control of Chlamydia trachomatis urogenital
infection will likely require a vaccine. We have assessed the protective effect of an outer …

Outer membrane proteins preferentially load MHC class II peptides: implications for a Chlamydia trachomatis T cell vaccine

KP Karunakaran, H Yu, X Jiang, Q Chan, KM Moon… - Vaccine, 2015 - Elsevier
CD4 T cell immune responses such as interferon-γ and tumor necrosis factor-α secretion are
necessary for Chlamydia immunity. We used an immunoproteomic approach in which …

Vaccination against Chlamydia Genital Infection Utilizing the Murine C. muridarum Model

CM Farris, RP Morrison - Infection and immunity, 2011 - Am Soc Microbiol
Chlamydia trachomatis genital infection is a worldwide public health problem, and
considerable effort has been expended on developing an efficacious vaccine. The murine …

Identification of Immunodominant Antigens by Probing a Whole Chlamydia trachomatis Open Reading Frame Proteome Microarray Using Sera from Immunized Mice

MI Cruz-Fisher, C Cheng, G Sun, S Pal… - Infection and …, 2011 - Am Soc Microbiol
Chlamydia trachomatis infections can lead to severe chronic complications, including
trachoma, ectopic pregnancy, and infertility. The only effective approach to disease control is …

Protection promoted by pGP3 or pGP4 against Chlamydia muridarum is mediated by CD4+ cells in C57BL/6N mice

T Mosolygó, ÁM Szabó, EP Balogh, I Faludi, DP Virók… - Vaccine, 2014 - Elsevier
Urogenital tract infection with Chlamydia trachomatis is a leading cause of sexually
transmitted infections. There is currently no commercially available vaccine against C …

Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine.

GO Ifere, Q He, JU Igietseme, GA Ananaba… - … , and infection= Wei …, 2007 - europepmc.org
Background and purpose Genital infections due to Chlamydia trachomatis pose a
considerable public health challenge worldwide and a vaccine is urgently needed to protect …

Validation of the Chlamydia trachomatis genital challenge pig model for testing recombinant protein vaccines

K Schautteet, E Stuyven, E Cox… - Journal of medical …, 2011 - microbiologyresearch.org
Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen that is
the leading cause of bacterial sexually transmitted disease in humans in developing …