Protection against a chlamydial respiratory challenge by a chimeric vaccine formulated with the Chlamydia muridarum major outer membrane protein variable domains using the …

DF Tifrea, S Pal, J Fairman, P Massari, LM de La Maza - npj Vaccines, 2020 - nature.com
Chlamydia trachomatis is the most frequently detected sexually transmitted bacterial
pathogen in the world. Attempts to control these infections with screening programs and …

PmpG303-311, a Protective Vaccine Epitope That Elicits Persistent Cellular Immune Responses in Chlamydia muridarum-Immune Mice

RM Johnson, H Yu, MS Kerr, JE Slaven… - Infection and …, 2012 - Am Soc Microbiol
Urogenital Chlamydia serovars replicating in reproductive epithelium pose a unique
challenge to host immunity and vaccine development. Previous studies have shown that …

A multi-epitope vaccine based on Chlamydia trachomatis major outer membrane protein induces specific immunity in mice

J Tu, B Hou, B Wang, X Lin, W Gong… - Acta Biochim …, 2014 - academic.oup.com
We evaluated the immunogenicity and efficacy of a candidate vaccine comprising the major
outer membrane protein (MOMP) multi-epitope of Chlamydia trachomatis. A short gene of …

Chlamydia trachomatis-Infected Patients Display Variable Antibody Profiles against the Nine-Member Polymorphic Membrane Protein Family

C Tan, R Hsia, H Shou, CL Haggerty… - Infection and …, 2009 - Am Soc Microbiol
Genomic analysis of the Chlamydiaceae has revealed a multigene family encoding large,
putatively autotransported polymorphic membrane proteins (Pmps) with nine members in …

Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine

RC Brunham, J Rey-Ladino - Nature reviews immunology, 2005 - nature.com
Sexually transmitted Chlamydia trachomatis infections are a serious public-health problem.
With more than 90 million new cases occurring annually, C. trachomatis is the most common …

Characterization of a neutralizing monoclonal antibody directed at variable domain I of the major outer membrane protein of Chlamydia trachomatis C-complex …

Z Qu, X Cheng, LM de la Maza… - Infection and …, 1993 - Am Soc Microbiol
A monoclonal antibody (MAb), C10, that neutralized in vitro the infectivity of serovars C, I, J,
and L3 (members of the C and C-related complexes) of Chlamydia trachomatis was …

Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the …

S Pal, J Bravo, EM Peterson… - Infection and …, 2008 - Am Soc Microbiol
Monoclonal antibodies (MAbs) to the Chlamydia trachomatis mouse pneumonitis (MoPn)
major outer membrane protein (MOMP) were characterized for their ability to neutralize the …

Plasmid-deficient Chlamydia muridarum fail to induce immune pathology and protect against oviduct disease

CM O'Connell, RR Ingalls, CW Andrews… - The Journal of …, 2007 - journals.aai.org
Chlamydia trachomatis is the most prevalent sexually transmitted bacterial infection in the
world. In women, genital infection can cause endometritis and pelvic inflammatory disease …

The anti-idiotypic antibody to chlamydial glycolipid exoantigen (GLXA) protects mice against genital infection with a human biovar of Chlamydia trachomatis

JA Whittum-Hudson, D Rudy, H Gerard, G Vora… - Vaccine, 2001 - Elsevier
Despite more than three decades of anti-chlamydial vaccine research and improved vaccine
strategies with new technologies, no vaccine candidate has protected against heterologous …

Immunity to murine chlamydial genital infection

RP Morrison, HD Caldwell - Infection and immunity, 2002 - Am Soc Microbiol
Chlamydia trachomatis sexually transmitted infections cause considerable morbidity and
socioeconomic burden worldwide, despite significant advances in our understanding of the …