Isolation of recombinant fragments of the major outer-membrane protein of Chlamydia trachomatis: their potential as subunit vaccines

JW Conlan, S Ferris, IN Clarke, ME Ward - Microbiology, 1990 - microbiologyresearch.org
Recombinant fragments of the major outer-membrane protein (MOMP) of Chlamydia
trachomatis, expressed at high levels in Escherichia coli, were isolated and purified …

Profiling of Human Antibody Responses to Chlamydia trachomatis Urogenital Tract Infection Using Microplates Arrayed with 156 Chlamydial Fusion Proteins

J Sharma, Y Zhong, F Dong, JM Piper… - Infection and …, 2006 - Am Soc Microbiol
The available chlamydial genome sequences have made it possible to comprehensively
analyze host responses to all chlamydial proteins, which is essential for further …

Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon …

H Yu, X Jiang, C Shen, KP Karunakaran… - Infection and …, 2010 - Am Soc Microbiol
Major impediments to developing a Chlamydia vaccine lie in identifying immunologically
relevant T-cell antigens and delivery in a manner to stimulate protective immunity. Using an …

[HTML][HTML] Immunoreactivity and differential developmental expression of known and putative Chlamydia trachomatis membrane proteins for biologically variant serovars …

JP Gomes, R Hsia, S Mead, MJ Borrego, D Dean - Microbes and infection, 2005 - Elsevier
Chlamydia trachomatis is an intracellular bacterium that causes ocular and urogenital
diseases worldwide. Membrane proteins have only been partially characterized, and the …

Polymorphisms in the Nine Polymorphic Membrane Proteins of Chlamydia trachomatis across All Serovars: Evidence for Serovar Da Recombination and Correlation …

JP Gomes, A Nunes, WJ Bruno, MJ Borrego… - Journal of …, 2006 - Am Soc Microbiol
Chlamydia trachomatis is an intracellular bacterium responsible for ocular, respiratory, and
sexually transmitted diseases. The genome contains a nine-member polymorphic …

Antigenic variation of Chlamydia trachomatis

RS Stephens - Intracellular Parasitism, 2020 - taylorfrancis.com
This chapter suggests that the most likely form of antigenic variation for Chlamydia
trachomatis is allelic variation. Antigenic variation of the chlamydial major outer membrane …

Immunization with a peptide corresponding to chlamydial heat shock protein 60 increases the humoral immune response in C3H mice to a peptide representing …

VL Motin, LM de la Maza… - Clinical Diagnostic …, 1999 - Am Soc Microbiol
ABSTRACT C3H (H-2k) mice are susceptible to a vaginal challenge with human strains of
Chlamydia trachomatis and thus are a useful strain for testing potential Chlamydia vaccine …

Recombination in the Genome of Chlamydia trachomatis Involving the Polymorphic Membrane Protein C Gene Relative to ompA and Evidence for Horizontal Gene …

JP Gomes, WJ Bruno, MJ Borrego… - Journal of bacteriology, 2004 - Am Soc Microbiol
Genome sequencing of Chlamydia trachomatis serovar D has identified polymorphic
membrane proteins (Pmp) that are a newly recognized protein family unique to the …

Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge

DC Bulir, S Liang, A Lee, S Chong, E Simms, C Stone… - Vaccine, 2016 - Elsevier
Chlamydia trachomatis infections in women are often asymptomatic and if left untreated can
lead to significant late sequelae including pelvic inflammatory disease and tubal factor …

Mimicry of a neutralizing epitope of the major outer membrane protein of Chlamydia trachomatis by anti-idiotypic antibodies

L Brossay, A Villeneuve, G Paradis, L Coté… - Infection and …, 1994 - Am Soc Microbiol
The major outer membrane protein (MOMP) is a primary target antigen for the development
of chlamydial vaccine. This protein is composed of four variable domains (I to IV) flanked by …