Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common
characteristic of various disorders. Therefore, proteins involved in apoptosis are prime …

BCL-XL, an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival.
However, the potential of BCL-XL as an anti-cancer target has been hampered by the on …

Abstract Targeting BCL-X L via PROTACs is a promising strategy in reducing BCL-X L
inhibition associated platelet toxicity. Recently, we reported potent BCL-X L PROTAC …

Anti-apoptotic protein BCL-X L plays a key role in tumorigenesis and cancer chemotherapy
resistance, rendering it an attractive target for cancer treatment. However, BCL-X L inhibitors …

Abstract BCL-X L is an anti-apoptotic protein that plays an important role in tumorigenesis,
metastasis, and intrinsic or therapy-induced cancer drug resistance. More recently, BCL-X L …

The induction of apoptosis in tumor cells represents a promising approach to the treatment
of cancer. Accordingly, compounds that interact with the Bcl-2 family of proteins, which are …

Apoptosis is the major mode of programmed cell death, which conduces to maintain tissue
homeostasis, clearance of abnormal cells and development of organisms. Over the past two …

This review focuses on the recent patents and use of small-molecule inhibitors (SMIs) of Bcl-
2 family proteins as therapeutic agents against cancer. Bcl-2 members are crucial regulators …

Bcl-xL is a member of the Bcl-2 family of proteins that are implicated to play a vital role in
several diseases including cancer. Bcl-xL suppresses apoptosis; thus the inhibition of Bcl-xL …

BCL-XL and BCL-2 are important targets for cancer treatment. BCL-XL specific proteolysis-
targeting chimeras (PROTACs) have been developed to circumvent the on-target platelet …