Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes

P Strączyńska, K Papis, E Morawiec… - Reproductive Biology …, 2022 - Springer
In vitro fertilization (IVF) is currently one of the most effective methods of infertility treatment.
An alternative to commonly used ovarian hyperstimulation can become extracorporeal …

Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes

K Wigglesworth, KB Lee, MJ O'Brien… - Proceedings of the …, 2013 - National Acad Sciences
Coordinated regulation of oocyte and ovarian follicular development is essential for fertility.
In particular, the progression of meiosis, a germ cell-specific cell division that reduces the …

Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes

Y Wang, N Kong, N Li, X Hao, K Wei, X Xiang… - …, 2013 - academic.oup.com
In preovulatory ovarian follicles, the oocyte is maintained in meiotic prophase arrest by
natriuretic peptide precursor C (NPPC) and its receptor natriuretic peptide receptor 2 …

Hormonal control of mammalian oocyte meiosis at diplotene stage

M Zhang, G Xia - Cellular and Molecular Life Sciences, 2012 - Springer
Mammalian oocytes grow and undergo meiosis within ovarian follicles. Fully grown oocytes
are arrested at the first meiotic prophase by a mural granulosa origin “arrester” until a surge …

Molecular control of oocyte meiotic arrest and resumption

L Liu, N Kong, G Xia, M Zhang - Reproduction, fertility and …, 2013 - CSIRO Publishing
Mammalian oocytes within Graafian follicles are arrested at prophase I by factors from
surrounding follicle cells, and resume meiosis after an LH surge from the pituitary. The …

Natriuretic peptide receptor 2 (NPR2) localized in bovine oocyte underlies a unique mechanism for C-type natriuretic peptide (CNP)-induced meiotic arrest

G Xi, L An, Z Jia, K Tan, J Zhang, Z Wang, C Zhang… - Theriogenology, 2018 - Elsevier
Meiosis is of prime importance for successful gametogenesis, and insufficient maintenance
of oocyte meiotic arrest compromises oocyte developmental competence. Recent studies …

Immature oocytes from unprimed juvenile mice become a valuable source for embryo production when using C-type natriuretic peptide as essential component of …

S Romero, F Sánchez, F Lolicato… - Biology of …, 2016 - academic.oup.com
C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor 2 (NPR2) play a
paramount role in the maintenance of oocyte meiotic arrest in antral follicles via the …

[HTML][HTML] Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes …

JW Robinson, M Zhang, LC Shuhaibar, RP Norris… - Developmental …, 2012 - Elsevier
In preovulatory ovarian follicles of mice, meiotic prophase arrest in the oocyte is maintained
by cyclic GMP from the surrounding granulosa cells that diffuses into the oocyte through gap …

Estradiol Promotes and Maintains Cumulus Cell Expression of Natriuretic Peptide Receptor 2 (NPR2) and Meiotic Arrest in Mouse Oocytes In Vitro

M Zhang, YQ Su, K Sugiura, K Wigglesworth… - …, 2011 - academic.oup.com
Natriuretic peptide type C (NPPC) and its cognate receptor natriuretic peptide receptor 2
(NPR2) are essential for maintaining meiotic arrest in mouse oocytes residing in Graafian …

CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR‐mediated signaling in preovulatory follicles

T Tsuji, C Kiyosu, K Akiyama… - Molecular reproduction …, 2012 - Wiley Online Library
Oocyte meiosis is arrested at prophase I by factors secreted from surrounding somatic cells
after oocytes acquire meiotic competence at an early antral stage, and meiosis resumes in …