Sleep exerts many effects on mammalian forebrain networks, including homeostatic effects
on both synaptic strengths and firing rates. We used large-scale recordings to examine the …

The need to sleep grows with the duration of wakefulness and dissipates with time spent
asleep, a process called sleep homeostasis. What are the consequences of staying awake …

It has been hypothesized that waking leads to higher-firing neurons, with increased energy
expenditure, and that sleep serves to return activity to baseline levels. Oscillatory activity …

Healthy aging is associated with marked effects on sleep, including its daily amount and
architecture, as well as the specific EEG oscillations. Neither the neurophysiological …

Highlights•A mechanism for NREM-mediated homeostatic function is proposed.•The
mechanism relies on sequential activity at the DOWN→ UP transition.•Spiking from high-to …

Sleep is composed of an alternating sequence of REM and non-REM episodes, but their
respective roles are not known. We found that the overall firing rates of hippocampal CA1 …

Research findings over the past two decades have supported a link between sleep states
and synaptic plasticity. Numerous mechanistic hypotheses have been put forth to explain …

The mammalian brain oscillates through three distinct global activity states: wakefulness,
non‐rapid eye movement (NREM) sleep and REM sleep. The regulation and function of …

Sleep is assumed to subserve homeostatic processes in the brain; however, the set point
around which sleep tunes circuit computations is unknown. Slow-wave activity (SWA) is …

Both neocortical and hippocampal networks organize the firing patterns of their neurons by
prominent oscillations during sleep, but the functional role of these rhythms is not well …