Passage in mice of opportunistic pathogens such as Cryptococcus neoformans is known to
increase virulence, but little is known about the molecular mechanisms involved in virulence …

Iron is an essential nutrient in both pathogens and vertebrate host, and contributes the
elaboration of key virulence factors including pigment melanin and polysaccharide capsule …

The mechanisms by which pathogens sense and transport iron are important during
infection, because of the low availability of free iron in the mammalian host. Iron is a key …

The ubiquitous pathogen Cryptococcus neoformans is the most common cause of fungal
meningoencephalitis worldwide. This fungus produces an antiphagocytic polysaccharide …

Amino acid biosynthetic pathways that are absent in mammals are considered an attractive
target for antifungal therapy. Leucine biosynthesis is one such target pathway, consisting of …

Cryptococcus neoformans is a facultative intracellular pathogen. The most distinctive feature
of C. neoformans is a polysaccharide capsule that enlarges depending on environmental …

Few fungi are pathogenic to humans. Of these, Cryptococcus neoformans has emerged as
an important cause of mortality in immunocompromised patients, especially those with AIDS …

The ability of Cryptococcus neoformans to cause disease in humans varies significantly
among strains with highly related genotypes. In general, environmental isolates of …

Cryptococcus neoformans is an important human fungal pathogen for which the external
environment is its primary niche. Previous work has shown that two nonessential acetyl-CoA …

Abs facilitate humoral immunity via the classical mechanisms of opsonization, complement
activation, Ab-dependent cellular cytotoxicity, and toxin/viral neutralization. There is also …