Background The feasibility of beta cell mass (BCM) imaging and quantification with positron
emission tomography (PET) in the pancreas is controversial. In an effort to shed some light …

At present, the onset and progress of diabetes, and the efficacy of potential treatments, can
only be assessed through indirect means, ie blood glucose, insulin, or C‐peptide …

Diabetes is a disorder characterized by beta-cell loss or exhaustion and insulin deficiency.
At present, knowledge is lacking on the underlying causes and for the therapeutic recovery …

Since diabetes is becoming a global epidemic, there is a great need to develop early β-cell
specific diagnostic techniques for this disorder. There are two types of diabetes (ie, type 1 …

Diabetes is a chronic metabolic disease affecting over 400 million people worldwide and
one of the leading causes of death, especially in developing nations. The disease is …

Purpose We have generated transgenic mouse lines expressing the positron emission
tomography (PET) reporter gene, sr39tk, under the control of the mouse insulin I promoter …

Beta cells assume a fundamental role in maintaining blood glucose homeostasis through
the secretion of insulin, which is contingent on both beta cell mass and function, in response …

TO THE EDITOR: We read with interest the review by Ichise and Harris (1), who proposed
11C-dihydrotetrabenazine (11C-DTBZ) PET as a potentially useful method for imaging b …

As both type 1 (T1DM) and type 2 diabetes mellitus (T2DM)—albeit distinct etiopathogenics—
are associated with a functional loss of β-cell mass (BCM), an important approach to prevent …

Abstract Single Photon Emission Computed Tomography (SPECT) has become a promising
experimental approach to monitor changes in β-cell mass (BCM) during diabetes …