Vascular cognitive impairment, dementia, aging and energy demand. A vicious cycle

A Popa-Wagner, AM Buga, B Popescu… - Journal of neural …, 2015 - Springer
To a great extent, cognitive health depends on cerebrovascular health and a deeper
understanding of the subtle interactions between cerebrovascular function and cognition is …

[HTML][HTML] Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

O Shabir, J Berwick, SE Francis - BMC neuroscience, 2018 - Springer
Efficient blood supply to the brain is of paramount importance to its normal functioning and
improper blood flow can result in potentially devastating neurological consequences …

The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia

C Iadecola - Acta neuropathologica, 2010 - Springer
There is increasing evidence that cerebrovascular dysfunction plays a role not only in
vascular causes of cognitive impairment but also in Alzheimer's disease (AD). Vascular risk …

The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged

S Craft - Archives of neurology, 2009 - jamanetwork.com
In recent years a rapidly increasing number of studies has focused on the relationship
between dementia and metabolic disorders such as diabetes, obesity, hypertension, and …

[HTML][HTML] The role of insulin in the vascular contributions to age-related dementia

TM Hughes, S Craft - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
In addition to its well-known role in energy metabolism in the body, insulin is a vasoactive
hormone that regulates peripheral and cerebral blood flow and neuronal function. Vascular …

Neurovascular unit dysregulation, white matter disease, and executive dysfunction: the shared triad of vascular cognitive impairment and Alzheimer disease

A Levit, V Hachinski, SN Whitehead - Geroscience, 2020 - Springer
Executive dysfunction is the most important predictor for loss of independence in dementia.
As executive function involves the coordination of distributed cerebral functions, executive …

Contribution of cerebral microvascular mechanisms to age-related cognitive impairment and dementia

X Fang, RF Crumpler, KN Thomas… - Physiology …, 2022 - akjournals.com
Cognitive impairment and dementia are significant health burdens worldwide. Aging,
hypertension, and diabetes are the primary risk factors for Alzheimer's disease and …

Age‐related changes in cerebrovascular health and their effects on neural function and cognition: A comprehensive review

B Zimmerman, B Rypma, G Gratton… - …, 2021 - Wiley Online Library
The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

Vascular contribution to cognition in stroke and Alzheimer's disease

Y Yang, J Fuh, VCT Mok - Brain Science Advances, 2018 - journals.sagepub.com
Vascular factors to cognitive impairment in degenerative on non-degenerative diseases
have been reported, examined, and debated for several decades. The various definitions of …

Cerebral microvascular pathology in aging and Alzheimer's disease

E Farkas, PGM Luiten - Progress in neurobiology, 2001 - Elsevier
The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of …