Prostate cancer is one of the most common malignancies in men worldwide. Current clinical
screening ensures that most prostate cancers are diagnosed while still organ confined, but …

Epigenetic modifications, such as DNA methylation, are widely studied in cancer as they are
stable and easy to measure genome wide. DNA methylation changes have been used to …

Aberrant DNA methylation is one of the hallmarks of carcinogenesis and has been
recognized in cancer cells for more than 20 years. The role of DNA methylation in malignant …

Abstract Background Prostate cancer (PCa) has the highest incidence rates of cancers in
men in western countries. Unlike several other types of cancer, PCa has few genetic drivers …

Epigenetic modifications, such as DNA methylation, is widely studied in cancer. DNA
methylation patterns have been shown to distinguish between benign and malignant tumors …

A critical need in understanding the biology of prostate cancer is characterizing the
molecular differences between indolent and aggressive cases. Because DNA methylation …

After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools
available to interrogate it, we consider the literature surrounding DNA methylation as …

Background: Prostate cancer (PCa) harbors a myriad of genomic and epigenetic defects.
Cytosine methylation of CpG-rich promoter DNA is an important mechanism of epigenetic …

Prostate cancer (PCa) is the most prevalent cancer, a significant contributor to morbidity and
a leading cause of cancer-related death in men in Western industrialized countries. In …

Epigenetic silencing mediated by CpG methylation is a common feature of many cancers.
Characterizing aberrant DNA methylation changes associated with tumor progression may …