Background Nitric oxide (NO) as a vaso-and cardio-protective agent could reduce
vasomotor dysfunction in different cardiovascular diseases. One of the current therapeutics …

NO, constitutively produced by endothelial NO synthase (eNOS), plays a key regulatory role
in vascular wall homeostasis. We generated transgenic (Tg) mice overexpressing eNOS in …

Objectives: We sought to examine the hypothesis that a pharmacologic up-regulation of
endothelial nitric oxide synthase (eNOS) combined with a reversal of eNOS uncoupling …

Objectives: Endothelial dysfunction and oxidative stress are associated with hypertension
but whether endothelial superoxide may play a role in the early development of essential …

We tested the hypothesis that nitric oxide (NO) released by endothelial NO synthase (eNOS)
is not only important in blood pressure regulation but also involved in cardiac function and …

Cholesterol feeding results in impaired endothelium dependent vasorelaxation. The role of
nitric oxide in this process is unclear. The aim of this study was to evaluate the role of nitric …

The aim of the study was to evaluate the possible contribution of non-endothelial eNOS to
the regulation of blood pressure (BP). To accomplish this, a double transgenic strain …

Relaxation to acetylcholine (ACh) and calcium ionophore (A-23187) is absent in aortas from
endothelial nitric oxide synthase (eNOS)-deficient (eNOS-/-) mice. We hypothesized that …

BACKGROUND AND PURPOSE Nitric oxide (NO) plays an important role in endothelial
function, and impaired NO production is involved in hypertension. Therefore, compounds …

In large vessels, endothelium-dependent vasodilation is mainly attributed to endothelial
nitric oxide synthase (eNOS)-derived NO production. However, we have recently shown that …