[HTML][HTML] SLC26A3 inhibitor identified in small molecule screen blocks colonic fluid absorption and reduces constipation
SLC26A3 (downregulated in adenoma; DRA) is a Cl–/anion exchanger expressed in the
luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl …
luminal membrane of intestinal epithelial cells, where it facilitates electroneutral NaCl …
Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action
O Cil, MO Anderson, L de Souza Goncalves… - European journal of …, 2023 - Elsevier
The anion exchanger protein SLC26A3 (down-regulated in adenoma, DRA) is expressed in
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …
the luminal membrane of intestinal epithelial cells in colon, where it facilitates the absorption …
[HTML][HTML] SLC26A6-selective inhibitor identified in a small-molecule screen blocks fluid absorption in small intestine
O Cil, PM Haggie, JAT Tan, AA Rivera, AS Verkman - JCI insight, 2021 - ncbi.nlm.nih.gov
SLC26A6 (also known as putative anion transporter 1 [PAT1]) is a Cl–/HCO 3–exchanger
expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl–and fluid …
expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl–and fluid …
4, 8-Dimethylcoumarin inhibitors of intestinal anion exchanger slc26a3 (downregulated in adenoma) for anti-absorptive therapy of constipation
The chloride/bicarbonate exchanger SLC26A3 (downregulated in adenoma) is expressed
mainly in colonic epithelium, where it dehydrates the stool by facilitating the final step of …
mainly in colonic epithelium, where it dehydrates the stool by facilitating the final step of …
[引用][C] HCO3− secretion by SLC26A3 and mucosal defence in the colon
H Ishiguro - Acta Physiologica, 2014 - Wiley Online Library
SLC26A3, previously named DRA (down-regulatedin-adenoma), is a member of the SLC26
anion transporter family. SLC26A3 is abundantly expressed in the apical membrane of …
anion transporter family. SLC26A3 is abundantly expressed in the apical membrane of …
[HTML][HTML] Small-molecule inhibitor of intestinal anion exchanger SLC26A3 for treatment of hyperoxaluria and nephrolithiasis
Nephrolithiasis is a common and recurrent disease affecting 9% of the US population.
Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two …
Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two …
Slc26a3 deficiency is associated with loss of colonic HCO3− secretion, absence of a firm mucus layer and barrier impairment in mice
F Xiao, Q Yu, J Li, MEV Johansson, AK Singh… - Acta …, 2014 - Wiley Online Library
Aim Downregulated in adenoma (DRA, Slc26a3) is a member of the solute carrier family 26
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …
(SLC 26), family of anion transporters, which is mutated in familial chloride‐losing diarrhoea …
Down-regulated in adenoma Cl/HCO3 exchanger couples with Na/H exchanger 3 for NaCl absorption in murine small intestine
NM Walker, JE Simpson, PF Yen, RK Gill, EV Rigsby… - Gastroenterology, 2008 - Elsevier
BACKGROUND & AIMS: Electroneutral NaCl absorption across small intestine contributes
importantly to systemic fluid balance. Disturbances in this process occur in both obstructive …
importantly to systemic fluid balance. Disturbances in this process occur in both obstructive …
[HTML][HTML] slc26a3 (dra)-deficient mice display chloride-losing diarrhea, enhanced colonic proliferation, and distinct up-regulation of ion transporters in the colon
CW Schweinfest, DD Spyropoulos… - Journal of Biological …, 2006 - ASBMB
Mutations in the SLC26A3 (DRA (down-regulated in adenoma)) gene constitute the
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …
molecular etiology of congenital chloride-losing diarrhea in humans. To ascertain its role in …
Slc26a3 deletion alters pH‐microclimate, mucin biosynthesis, microbiome composition and increases the TNFα expression in murine colon
A Kini, AK Singh, B Riederer, I Yang, X Tan… - Acta …, 2020 - Wiley Online Library
Abstract Aim SLC26A3 (DRA) mediates the absorption of luminal Cl− in exchange for
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …
HCO3− in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) …