The excretion of endogenous and exogenous compounds is a fundamental aspect of renal
function, which, by necessity, exposes the kidney to high concentrations of these substances …

Although the concept of nephrotoxicity has been recognized for more than 80 years, interest
in nephrotoxins has intensified dramatically over the past two decades. Much of this …

Greater awareness of environmental toxins and improved diagnostic methods in nephrology
have recently identified toxic nephropathy as a distinct segment of renal disease. Toxic …

Because the kidney is vital to total body homeostasis, a toxic insult to the kidney can have
profound effects–an insult of sufficient severity can permanently damage renal tissue …

The neonatal kidney is predisposed to nephrotoxic AKI. Our ability to improve outcomes for
this vulnerable group depends on a heightened awareness of this issue. It is important for …

Nephrotoxin-induced acute kidney injury (AKI) is a considerable risk among hospitalized
children. The development and use of a proactive, nephrotoxin screening system seems to …

The contribution of nephrotoxic medications to the development of acute kidney injury (AKI)
is becoming better understood concomitant with the increased incidence of AKI in children …

Background Rates of nephrotoxic AKI are not well described in adults due to lack of a clear
definition, debate over which drugs should be considered nephrotoxins, and illness-related …

Toxic nephropathies are a clinically common group of disorders characterized by toxin-
induced renal injury that can affect the glomerulus, vasculature, or tubulointerstitium. Various …

The kidneys play a large role in the way we handle and excrete drugs. This makes
assessment of renal function key when prescribing drugs, to ensure patient safety. Drugs …