Background Though acute kidney injury (AKI) is often multifactorial, investigators are now
emphasizing the specific contribution of nephrotoxins. This study examines the …

Both acute and chronic renal failure are reported in the context of nephrotoxicity. This
overview of some major nephrotoxins reflects both the magnitude and the cost of this …

Review on uremic toxins: Classification, concentration, and interindividual variability.
Background The choice of the correct concentration of potential uremic toxins for in vitro, ex …

Exposure of humans to nephrotoxins can occur through ingestion, inhalation or contact.
While the offending agent IS often a prescribed drug or illicit compound, the two other …

Acute kidney injury (AKI) is a common condition with a high risk of death. Nephrotoxicity
occurs when kidney-specific detoxification and excretion do not work properly due to the …

Drug-induced kidney toxicity is a significant contributor to acute kidney injury. Nephrotoxic
drugs need to be identified during nonclinical testing to highlight potential risk translatable to …

Acute kidney injury (AKI) is a serious problem occurring in anywhere between 8 and 30% of
children in the intensive care unit. Up to 25% of these cases are believed to be the result of …

Renal metabolism and nephron structures are extremely complex and, therefore, vulnerable
in a variety of ways. Since many drugs and other substances are capable of causing serious …

There are a variety of experimental models of acute renal dysfunction and injury for the study
of nephrotoxicity. These models include whole animals, isolated perfused kidneys …