Role of the NFκB-signaling pathway in cancer

L Xia, S Tan, Y Zhou, J Lin, H Wang… - OncoTargets and …, 2018 - Taylor & Francis
Cancer is a group of cells that malignantly grow and proliferate uncontrollably. At present,
treatment modes for cancer mainly comprise surgery, chemotherapy, radiotherapy …

NF‐κB as a potential molecular target for cancer therapy

CH Lee, YT Jeon, SH Kim, YS Song - Biofactors, 2007 - Wiley Online Library
Nuclear factor κB (NF‐κB), a transcription factor, plays an important role in carcinogenesis
as well as in the regulation of immune and inflammatory responses. NF‐κB induces the …

NF-κB in cancer: a matter of life and death

BB Aggarwal, B Sung - Cancer discovery, 2011 - AACR
Activation of NF-κB has been linked to various cellular processes in cancer, including
inflammation, transformation, proliferation, angiogenesis, invasion, metastasis …

NF-κB, an active player in human cancers

Y Xia, S Shen, IM Verma - Cancer immunology research, 2014 - AACR
NF-κB comprises a family of five transcription factors that form distinct protein complexes,
which bind to consensus DNA sequences at promoter regions of responsive genes …

Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study

H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

NF-κB in cancer therapy

F Li, J Zhang, F Arfuso, A Chinnathambi, ME Zayed… - Archives of …, 2015 - Springer
The transcription factor nuclear factor kappa B (NF-κB) has attracted increasing attention in
the field of cancer research from last few decades. Aberrant activation of this transcription …

Evidence for the involvement of the master transcription factor NF-κB in cancer initiation and progression

YR Puar, MK Shanmugam, L Fan, F Arfuso, G Sethi… - Biomedicines, 2018 - mdpi.com
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Transcriptional regulation during aberrant activation of NF-κB signalling in cancer

K Deka, Y Li - Cells, 2023 - mdpi.com
The NF-κB signalling pathway is a major signalling cascade involved in the regulation of
inflammation and innate immunity. It is also increasingly recognised as a crucial player in …

Deregulation of NF-κB and its upstream kinases in cancer

SC Sun, G Xiao - Cancer and Metastasis Reviews, 2003 - Springer
The transcription factor NF-κB is known for its function in regulating immune and
inflammatory responses. However, recent evidence suggests that NF-κB also plays a pivotal …

Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches

MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …