Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

SW Tuffs, MI Goncheva, SX Xu… - Proceedings of the …, 2022 - National Acad Sciences
Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of
human diseases. Staphylococcal superantigens (SAgs) constitute a family of exotoxins from …

Superantigens Subvert the Neutrophil Response To Promote Abscess Formation and Enhance Staphylococcus aureus Survival In Vivo

SX Xu, KJ Gilmore, PA Szabo, JJ Zeppa… - Infection and …, 2014 - Am Soc Microbiol
Staphylococcus aureus is a versatile bacterial pathogen that produces T cell-activating
toxins known as superantigens (SAgs). Although excessive immune activation by SAgs can …

Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization

SX Xu, KJ Kasper, JJ Zeppa, JK McCormick - Toxins, 2015 - mdpi.com
Superantigens (SAgs) are potent microbial toxins that function to activate large numbers of T
cells in a T cell receptor (TCR) Vβ-specific manner, resulting in excessive immune system …

Staphylococcal superantigens in colonization and disease

SX Xu, JK McCormick - Frontiers in cellular and infection microbiology, 2012 - frontiersin.org
Superantigens (SAgs) are a family of potent immunostimulatory exotoxins known to be
produced by only a few bacterial pathogens, including Staphylococcus aureus. More than …

Population analysis of Staphylococcus aureus reveals a cryptic, highly prevalent superantigen SElW that contributes to the pathogenesis of bacteremia

M Vrieling, SW Tuffs, G Yebra, MY van Smoorenburg… - Mbio, 2020 - Am Soc Microbiol
Staphylococcal superantigens (SAgs) are a family of secreted toxins that stimulate T cell
activation and are associated with an array of diseases in humans and livestock. Most SAgs …

Staphylococcal toxic shock syndrome: superantigen-mediated enhancement of endotoxin shock and adaptive immune suppression

K Kulhankova, J King, W Salgado-Pabón - Immunologic research, 2014 - Springer
Infectious diseases caused by Staphylococcus aureus present a significant clinical and
public health problem. S. aureus causes some of the most severe hospital-associated and …

Staphylococcal superantigens interact with multiple host receptors to cause serious diseases

CS Stach, A Herrera, PM Schlievert - Immunologic research, 2014 - Springer
Staphylococcus aureus strains that cause human diseases produce a large family of
pyrogenic toxin superantigens (SAgs). These include toxic shock syndrome toxin-1 (TSST …

Superantigen-Producing Staphylococcus aureus Elicits Systemic Immune Activation in a Murine Wound Colonization Model

CK Kim, MJ Karau, KE Greenwood-Quaintance… - Toxins, 2015 - mdpi.com
Staphylococcus aureus, the most common cause of wound infection, produces several
exotoxins, including superantigens (SAgs). SAgs are the potent activators of the immune …

A novel core genome-encoded superantigen contributes to lethality of community-associated MRSA necrotizing pneumonia

GJ Wilson, KS Seo, RA Cartwright, T Connelley… - PLoS …, 2011 - journals.plos.org
Bacterial superantigens (SAg) stimulate T-cell hyper-activation resulting in immune
modulation and severe systemic illnesses such as Staphylococcus aureus toxic shock …